Fig. 2

Relationship between age and menopause with quantitative tissue composition metrics of the normal breast. Locally weighted scatter plot smoothing (Lowess) functions were used to plot the residuals estimated in multivariable linear regression models for each tissue composition metric as a function of age. Lowess plots were constructed overall (A) and stratified by menopausal status (B). Pre- and postmenopausal status were defined by combining information on self-reported menopausal status, age (< 55 years (premenopausal) versus ≥ 55 years (postmenopausal)), bilateral oophorectomy, and having had a uterine ablation