Fig. 1
From: RAGE inhibition blunts insulin-induced oncogenic signals in breast cancer
Co-expression of RAGE and IR in BC patients. Breast cancer patients of the METABRIC cohort [17] ordered according to RAGE expression levels (x-axis). The color bar gradient stands for range of the most significant points‐ of‐ separation of the population (low‐ high significance = blue‐ yellow gradient) based on RAGE expression and survival of each patient. A Kaplan–Meier curve showing the correlation between RAGE expression and breast cancer specific survival (BCS) in the METABRIC cohort of breast cancer patients (B). Box plot showing the expression levels of RAGE (C) and IR D in BC patients stratified by tumor stage. Scatter plot depicting the correlation between RAGE and IR expression levels in BC samples of the METABRIC cohort (E). The Pearson correlation coefficient (r) and the relative p-value are shown (E). Kaplan–Meier curve showing the correlation between RAGE expression and BCS in the METABRIC cohort of BC patients (F). (***) p < 0.001; (****) p < 0.0001