Neutrophils in triple-negative breast cancer: an underestimated player with increasingly recognized importance

Breast Cancer Research

Table 1 Preclinical approaches targeting neutrophils in TNBC

Target	Intervention	Effects on neutrophils	References
Arg1/Nos2	l-Arginine supplementation	Reduce effects of arginine depletion	Cao et al. [87]
Cholesterol synthesis	Simvastatin, berberine	Blocking ASPP2-depletion induced NETs formation	Tang et al. [77]
Class I HDACs	Entinostat	Downregulation of Arg1	Christmas et al. [71]
c-MET	OMO-1	Reducing neutrophil infiltration	Steenbrugge et al. [68]
CXCR2	AZD5069	Blocking neutrophil chemotaxis	Safarulla et al. [69]
IL-1R	Anakinra	Reducing propensity for NET formation	Gomes et al. [78]
LXR	RGX-104	Induction of apoptosis	Tavazoie et al. [74]
PDE5	Sildenafil	Downregulation of Arg1 and Nos2	Serafini et al. [70]
RAR/RXR	All-trans retinoic acid	Promoting differentiation of MDSCs into mature cells	Bauer et al. [88]

ISSN: 1465-542X