Fig. 7
From: Transcriptionally regulated miR-26a-5p may act as BRCAness in Triple-Negative Breast Cancer
miR-26a-5p upregulation promotes the sensitivity of Olaparib and drug combination. A MDA-MB-231 cells were transfected with miR-26a-5p mimics and normal control. Different concentrations of Olaparib were diluted with medium containing 1% FBS to incubate cell lines for 72 h. CCK8 was used to detect cytotoxicity. B CCK8 was used to detect cytotoxicity of the drug combination of Cisplatin and Olaparib in MDA-MB-231 overexpressing miR-26a-5p and normal control. C, D CCK8 was used to detect the indicated drug effect on BT549 cells. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. control. N.S not significant. n = 3