Fig. 8

RHAMM expression is heterogeneous in wildtype primary tumors of MMTV-PyMT mice but is reduced in lung metastases. A, B Wildtype primary MMTV-PyMT tumors express RHAMM in a heterogeneous manner. C–F show the varying levels of RHAMM expression in lung colonies of wildtype mice. RHAMM expression is highest in small lung colonies (C), and low (D) to negative (E, F) in larger colonies. RHAMM is consistently expressed in the lung microenvironment (C–F)