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Table 4 Cross-classification of early pregnancy estradiol and progesterone and breast cancer risk: Northern Sweden Maternity Cohort

From: Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the Northern Sweden Maternity Cohort

 

Estradiol/progesterone

Low/low (<median/<median)

Low/high (<median/≥median)

High/low (≥median/<median)

High/high (≥median/≥median)

All women

Cases/controls

66/141

32/59

47/56

75/145

OR (95% CI)

Reference

1.14 (0.67–1.94)

1.87 (1.11–3.16)

1.10 (0.95–1.76)

ER+/PR+

Cases/controls

47/99

22/48

33/37

50/101

OR (95% CI)

Reference

0.92 (0.49–1.75)

1.81 (0.97–3.40)

0.98 (0.56–1.71)

ER–/PR–

Cases/controls

15/33

6/7

12/16

17/33

OR (95% CI)

Reference

1.63 (0.46–5.79)

1.42 (0.43–4.64)

0.80 (0.29–2.15)

  1. Conditional logistic regression controlling for gestational age at blood collection (continuous). Cases with reported ER+/PR– and ER–/PR+ tumors included in analysis of “all women”
  2. CI confidence interval, ER estrogen receptor, OR odds ratio, PR progesterone receptor
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Breast Cancer Research

ISSN: 1465-542X

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