| Cases/person years | HR1 (95% CI) | HR2 (95% CI) | HRinvasive (95% CI) |
---|---|---|---|---|
Volpara density grades | ||||
 VDG1 | 46/46,089 | ref | NA | ref |
 VDG2 | 143/99,086 | 1.49 (1.07 ; 2.07) | NA | 1.53 (1.07 ; 2.21) |
 VDG3 | 89/73,207 | 1.43 (0.99 ; 2.05) | NA | 1.41 (0.94 ; 2.10) |
 VDG4 | 21/20,314 | 1.39 (0.82 ; 2.36) | NA | 1.41 (0.79 ; 2.54) |
P trend | Â | 0.147 | Â | 0.219 |
Percent dense volume (in quartiles) | ||||
 Q1 (<4.8%) | 63/58,411 | ref | NA | ref |
 Q2 (4.8–6.4%) | 82/61,153 | 1.27 (0.91 ; 1.76) | NA | 1.27 (0.89 ; 1.81) |
 Q3 (6.4–9.8%) | 86/60,499 | 1.47 (1.06 ; 2.04) | NA | 1.52 (1.06 ; 2.17) |
 Q4 (>9.8%) | 68/58,633 | 1.36 (0.97 ; 1.94) | NA | 1.27 (0.86 ; 1.89) |
P trend | Â | 0.049 | Â | 0.119 |
Percent dense volume (per SD increase)# | 299/238,696 | 1.10 (0.97 ; 1.25) | NA | 1.08 (0.94 ; 1.24) |
Dense volume (VDG-like categories) | ||||
 C1 (<39.8 cm3) | 38/45,851 | ref | ref | ref |
 C2 (39.9–65.2 cm3) | 123/96,827 | 1.55 (1.08 ; 2.23) | 1.52 (1.03 ; 2.23) | 1.76 (1.14 ; 2.72) |
 C3 (65.3–110.1 cm3) | 101/74,190 | 1.76 (1.21 ; 2.56) | 1.69 (1.11 ; 2.57) | 1.99 (1.24 ; 3.17) |
 C4 (>110.1 cm3) | 37/21,828 | 2.40 (1.52 ; 3.79) | 2.30 (1.39 ; 3.80) | 2.03 (1.13 ; 3.67) |
P trend | Â | <0.001 | 0.002 | 0.014 |
Dense volume (in quartiles)* | ||||
 Q1 (<42.9 cm3) | 48/57,909 | ref | ref | ref |
 Q2 (42.9–57.8 cm3) | 71/59,364 | 1.46 (1.01 ; 2.10) | 1.45 (0.99 ; 2.13) | 1.62 (1.06 ; 2.48) |
 Q3 (57.9–78.9 cm3) | 80/60,359 | 1.67 (1.16 ; 2.39) | 1.67 (1.13 ; 2.47) | 1.86 (1.21 ; 2.87) |
 Q4 (>78.9 cm3) | 100/61,065 | 2.22 (1.57 ; 3.14) | 2.24 (1.51 ; 3.31) | 2.31 (1.49 ; 3.58) |
P trend | Â | <0.001 | <0.001 | <0.001 |
Dense volume (per SD increase)# | 299/238,696 | 1.27 (1.14 ; 1.43) | 1.27 (1.11 ; 1.45) | 1.22 (1.05 ; 1.41) |