BRCA promoter methylation in sporadic versus BRCA germline mutation-related breast cancers

Breast Cancer Research

Table 6 Relationship between BRCA1/2 methylation and clinicopathological variables in sporadic breast carcinomas

Sporadic carcinomas	Grades 1–2 vs. 3		Ductal vs. lobular tumors		ER-positive vs. ER-negative		PR-positive vs. PR-negative		HER2-positive vs. HER2-negative
Probe	Test statistic^a	p Value	Test statistic^a	p Value	Test statistic^a	p Value	Test statistic^a	p Value	Test statistic^a	p Value
BRCA1.1	12.230^b	0.001*	1.852^b	0.342	7.577^b	0.011*	6.753^b	0.016*	0.176^b	0.533
BRCA1.2	8.190^c	0.006*	0.026^b	1.000	6.689^c	0.014*	3.762^c	0.071	2.825^b	0.125
BRCA1.3	12.230^b	0.001*	1.852^b	0.342	7.577^b	0.011*	6.753^b	0.016*	0.176^b	0.533
BRCA1 total^c	8.190^c	0.006*	0.026^b	1.000	6.689^c	0.014*	3.762^c	0.071	2.825^b	0.125
BRCA2.1	6.577^b	0.015*	1.659^b	0.345	0.706^b	0.462	0.274^b	0.736	3.688^b	0.115
BRCA2.2	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
BRCA2.3	2.775^b	0.178	0.297^b	1.000	5.084^b	0.080	0.137^b	1.000	0.137^b	1.000
BRCA2.4	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
BRCA2 total^c	6.577^b	0.015*	1.659^c	0.345	0.706^c	0.462	0.274^c	0.736	3.688^c	0.115

Abbreviations: ER Estrogen receptor, HER2 Human epidermal growth factor receptor 2, N/A Not applicable, because one of the two variables (either the methylation probe or the clinicopathological variable) was a constant, PR Progesterone receptor
^aPearson’s chi-square test or Fisher’s exact test
^bFisher’s exact test
^cPearson’s chi-square test
*Statistically significant (two-sided p value <0.05)

ISSN: 1465-542X