Fig. 8From: Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situA schematic diagram illustrating the use of 3D pathomimetic mammary architecture and microenvironment engineering (MAME) cultures to identify a divergent interplay between tumor-suppressive myoepithelial cells (MEPs) and tumor-promoting cancer-associated fibroblasts (CAFs) that involves plasminogen activator inhibitor 1 (PAI-1), urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR), and interleukin 6 (IL-6) and alters the cellular and molecular phenotype of ductal carcinoma in situ (DCIS). ECM Extracellular matrix, rBM Reconstituted basement membraneBack to article page