Regular and low-dose aspirin, other non-steroidal anti-inflammatory medications and prospective risk of HER2-defined breast cancer: the California Teachers Study

Clarke, Christina A.; Canchola, Alison J.; Moy, Lisa M.; Neuhausen, Susan L.; Chung, Nadia T.; Lacey, James V.; Bernstein, Leslie

doi:10.1186/s13058-017-0840-7

Table 1 Participant characteristics and use of non-steroidal anti-inflammatory medications, California Teachers Study, 2005–2012

From: Regular and low-dose aspirin, other non-steroidal anti-inflammatory medications and prospective risk of HER2-defined breast cancer: the California Teachers Study

Characteristic	Number	Percentage
Age (years)^a
<40	1781	3.1
40–49	7020	12.3
50–59	16,651	29.1
60–69	15,779	27.6
70–79	10,482	18.3
80–89	4812	8.4
≥ 90	639	1.1
Race^b
White	50,250	87.9
Hispanic	2220	3.9
Asian/Pacific Islander	2135	3.7
Black	1183	2.1
Other/mixed	972	1.7
Missing	404	0.7
Age at menarche (years)^b
<12	12,799	22.4
≥ 12	43,635	76.3
Missing	730	1.3
Age at first full-term pregnancy (years)^b
Nulliparous	14,157	24.8
< 25	15,171	26.5
≥ 25	26,909	47.1
Missing	927	1.6
Total time breastfeeding (months)^b
Never or <12	40,567	71.0
≥ 12	15,446	27.0
Missing	1,151	2.0
History of a benign breast biopsy^b
No	47,812	83.6
Yes	9175	16.1
Missing	177	0.3
Family history of breast cancer (mother or sister)^b
No	48,736	85.3
Yes	6763	11.8
Missing data or participant was adopted	1665	2.9
History of hospitalization for myocardial infarction^c
No	56,586	99.0
Yes	578	1.0
History of diabetes mellitus^a
No	54,433	95.2
Yes	2715	4.8
Missing	16	0.0
Strenuous plus moderate physical activity in the past 3 years (hours per week)^a
<3	26,079	45.6
≥3	30,909	54.1
Missing	176	0.3
Alcohol consumption (grams per day)^a
None or <20	46,033	80.5
≥20	8652	15.1
Missing	2479	4.3
Body mass index (kg/m²)^a
<25.0	29,509	51.6
25.0–29.9	16,619	29.1
≥30.0	10,359	18.1
Missing	677	1.2
Menopausal status and hormone therapy (HT) use^a
Premenopausal	6314	11.1
Perimenopausal or postmenopausal
No HT in the last 5 years	27,397	47.9
Used HT in the last 5 years, but not currently using	10,142	17.7
Current HT use	11,420	20.0
Unknown menopausal status or HT use	1891	3.3
Regular-dose aspirin use at baseline^b
No NSAID use^d	37,075	64.9
No regular-dose aspirin use, but used ibuprofen	7002	12.3
Used 1–3 days/week	6340	11.1
Used 4+ days/week	5732	10.0
Unknown	1015	1.8
Low-dose aspirin use at the 10-year follow up^a
Never in the past 3 years
No NSAID use in the past 3 years^e	21,421	37.5
No low-dose aspirin use, use of 1+ type(s)	15,678	27.4
No low-dose aspirin use, unknown use of 1+ type(s)	1829	3.2
Former	2766	4.8
Current, 1–2 tablets/week	915	1.6
Current, 3–4 tablets/week	1163	2.0
Current, 5–6 tablets/week	1406	2.5
Current, 7+ tablets/week	10,421	18.2
Unknown	1565	2.7
Regular-dose aspirin use at the 10-year follow up^a
Never in the past 3 years
No NSAID use in the past 3 years^e	21,421	37.5
No regular-dose aspirin use, use of 1+ type(s)	23,451	41.0
No regular-dose aspirin use, unknown use for 1+ type(s)	2253	3.9
Former/irregular	2378	4.2
Current, 3+ tablets/week	6387	11.2
Unknown	1274	2.2
Ibuprofen use at the 10-year follow up^a
Never in the past 3 years
No NSAID use in the past 3 years^e	21,421	37.5
No ibuprofen use, use of 1+ type(s)	18,219	31.9
No ibuprofen use, unknown use for 1+ type(s)	1499	2.6
Former/irregular	3679	6.4
Current, 3+ tablets/week	10,382	18.2
Unknown	1964	3.4
Other non-steroidal use at the 10-year follow up^a
Never in the past 3 years
No NSAID use in the past 3 years^e	21,421	37.5
No other non-steroidal use, use of 1+ type(s)	25,529	44.7
No other non-steroidal use, unknown use for 1+ type(s)	2307	4.0
Former/irregular	2301	4.0
Current, 3+ tablets/week	4263	7.5
Unknown	1343	2.4
Cox-2 inhibitor use at the 10-year follow up^a
Never in the past 3 years^e
No NSAID use in the past 3 years^e	21,421	37.5
No Cox-2 inhibitor use, use of 1+ type(s)	28,055	49.1
No Cox-2 inhibitor use, unknown use for 1+ type(s)	2625	4.6
Former/irregular	2807	4.9
Current, 3+ tablets/week	1064	1.9
Unknown	1192	2.1

^aFrom the 10-year follow-up questionnaire completed in 2005–2006. ^bFrom the baseline questionnaire completed in 1995–1996. ^cFrom linkage with the Office of Statewide Health Planning and Development (OSHPD) hospital discharge database from 1991 until the 10-year follow-up questionnaire. ^dIncluded aspirin and ibuprofen used regularly (at least once a week) reported on the baseline questionnaire. ^eIncluded aspirin, low-dose aspirin, ibuprofen, Cox-2 inhibitors, and other NSAIDs currently used regularly (at least once a week) reported on the 10-year follow-up questionnaire. NSAID non-steroidal anti-inflammatory drug

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