From: Childhood body size and pubertal timing in relation to adult mammographic density phenotype
 |  | Mammographic density parameters | ||
---|---|---|---|---|
 |  |  | Absolute area | |
 |  | Percent density difference, | Dense area | Non-dense area |
Interval between pubertal stages | Category | percentage points (95% CI)a | difference, cm2 (95% CI)a | difference, cm2 (95% CI)a |
Thelarche to menarche, years | ||||
 A: | <0 | -0.4 (-4.8, 4.5) | -0.3 (-5.6, 5.5) | -3.9 (-17.6, 10.6) |
0 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) | |
1 | 2.2 (-0.7, 5.2) | 4.1 (0.5, 7.8) | -0.1 (-8.7, 8.8) | |
≥2 | 2.0 (-1.9, 6.2) | 4.0 (-0.7, 9.1) | -1.3 (-12.6, 10.8) | |
P trendb | 0.14 | 0.022 | 0.87 | |
 B: +BMI-adjusted | <0 | -0.5 (-4.5, 3.9) | -0.7 (-5.8, 5.0) | -4.7 (-15.3, 6.4) |
0 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) | |
1 | 1.7 (-0.9,4.5) | 4.1 (0.6, 7.8) | 1.9 (-4.8, 8.8) | |
≥2 | 2.1 (-1.5, 5.8) | 3.8 (-0.8, 8.7) | -1.7 (-10.5, 7.5) | |
P trendb | 0.13 | 0.019 | 0.64 | |
 C: +weight age 11 years | <0 | -1.3 (-5.3, 3.0) | -1.7 (-6.8, 3.8) | -3.5 (-14.2, 7.7) |
0 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) | |
1 | 1.7 (-1.0, 4.4) | 4.0 (0.6, 7.7) | 2.0 (-4.8, 8.9) | |
≥2 | 1.8 (-1.7, 5.5) | 3.4 (-1.1, 8.3) | -1.3 (-10.2, 7.9) | |
P trendb | 0.10 | 0.013 | 0.69 | |
Thelarche to regular cycles, years | ||||
 A: | <0 | -5.6 (-11.4, 1.1) | -7.8 (-14.7, 0.3) | 6.2 (-14.4, 28.9) |
0 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) | |
1 | 1.7 (-2.2, 5.9) | 1.8 (-2.9, 6.9) | -2.5 (-13.6, 9.3) | |
≥2 | 1.6 (-2.3, 5.9) | 2.6 (-2.3, 7.8) | 1.6 (-10.0, 13.8) | |
P trendb | 0.083 | 0.039 | 0.97 | |
 B: +BMI-adjusted | <0 | -2.9 (-8.6, 3.7) | -6.2 (-13.2, 2.0) | -7.3 (-23.0, 9.7) |
0 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) | |
1 | 1.8 (-1.8, 5.6) | 1.8 (-2.9, 6.7) | -3.5 (-12.3, 5.8) | |
≥2 | 2.5 (-1.2, 6.4) | 3.3 (-1.5, 8.5) | -1.5 (-10.6, 8.1) | |
P trendb | 0.068 | 0.029 | 0.87 | |
 C: +weight age 11 years | <0 | -3.6 (-9.2, 2.9) | -7.2 (-14.1, 0.8) | -6.6 (-22.5, 10.5) |
0 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) | |
1 | 1.8 (-1.8, 5.6) | 1.8 (-2.8, 6.7) | -3.4 (-12.3, 5.9) | |
≥2 | 2.3 (-1.4, 6.2) | 3.0 (-1.8, 8.1) | -1.4 (-10.5, 8.2) | |
P trendb | 0.064 | 0.028 | 0.89 |