From: Childhood body size and pubertal timing in relation to adult mammographic density phenotype
 |  | Mammographic density parameters | ||
---|---|---|---|---|
 |  |  | Absolute area | |
 |  | Percent density difference, | Dense area | Non-dense area |
Age at pubertal stage | Category | percentage points (95% CI)a | difference, cm2 (95% CI)a | difference, cm2 (95% CI)a |
Age at thelarche, years | ||||
 A: | ≤10 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) |
11–12 | 2.6 (-1.2-6.7) | 0.8 (-3.6, 5.5) | -8.8 (-19.3, 2.4) | |
≥13 | 5.7 (1.6-10.1) | 1.7 (-2.8, 6.6) | -23.1 (-33.1, -12.5) | |
P trendb | 0.002 | 0.42 | <0.001 | |
 B: +BMI-adjusted | ≤10 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) |
11–12 | 1.0 (-2.4, 4.6) | 0.0 (-4.2, 4.6) | -3.7 (-12.2, 5.1) | |
≥13 | 2.2 (-1.4, 6.0) | -0.1 (-4.5, 4.6) | -11.7 (-20.1, -3.0) | |
P trendb | 0.20 | 0.95 | 0.002 | |
 C: +weight age 11 years | ≤10 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) |
11–12 | 0.2 (-3.1, 3.8) | -1.0 (-5.1, 3.5) | -3.0 (-11.5, 5.9) | |
≥13 | 0.3 (-3.3, 4.1) | -2.5 (-6.8, 2.2) | -10.0 (-18.8, -0.7) | |
P trendb | 0.88 | 0.24 | 0.012 | |
Age at menarche, years | ||||
 A: | ≤12 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) |
13–14 | 4.7 (2.1, 7.3) | 3.5 (0.6, 6.6) | -12.7 (-19.5, -5.7) | |
≥15 | 6.9 (2.7, 11.3) | 5.7 (1.0, 10.8) | -17.7 (-28.1, -6.8) | |
P trendb | <0.001 | 0.003 | <0.001 | |
 B: +BMI-adjusted | ≤12 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) |
13–14 | 2.9 (0.6, 5.2) | 2.9 (0.0, 5.9) | -5.2 (-10.8, 0.6) | |
≥15 | 3.2 (-0.4, 7.1) | 4.2 (-0.4, 9.1) | -3.1 (-12.1, 6.2) | |
P trendb | 0.014 | 0.023 | 0.18 | |
 C: +weight age 11 years | ≤12 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) |
13–14 | 2.0 (-0.3, 4.4) | 1.7 (-1.1, 4.7) | -4.0 (-9.8, 1.9) | |
≥15 | 1.8 (-1.8, 5.6) | 2.3 (-2.2, 7.1) | -1.4 (-10.6, 8.2) | |
P trendb | 0.13 | 0.20 | 0.40 | |
Age at regular cycles, years | ||||
 A: | ≤12 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) |
13–14 | 5.2 (1.9, 8.7) | 5.4 (1.3, 9.7) | -10.0 (-18.8, -0.8) | |
≥15 | 6.4 (2.5, 10.5) | 5.3 (0.7, 10.3) | -12.4 (-22.4, -2.0) | |
P trendb | <0.001 | 0.013 | 0.014 | |
 B: +BMI-adjusted | ≤12 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) |
13–14 | 3.3 (0.3, 6.5) | 4.6 (0.6, 8.8) | -2.2 (-9.8, 5.6) | |
≥15 | 4.3 (0.8, 8.1) | 4.4 (-0.1, 9.2) | -4.3 (-12.8, 4.5) | |
P trendb | 0.010 | 0.036 | 0.33 | |
 C: +weight age 11 years | ≤12 | 0.0 (baseline) | 0.0 (baseline) | 0.0 (baseline) |
13–14 | 2.5 (-0.6, 5.7) | 3.6 (-0.4, 7.9) | -0.5 (-8.2, 7.5) | |
≥15 | 3.4 (-0.1, 7.1) | 3.4 (-1.1, 8.2) | -2.6 (-11.2, 6.5) | |
P trendb | 0.051 | 0.12 | 0.59 |