Fig. 7
From: Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment
Neutrophil depletion with anti-Ly6G antibody reduces the number of dense-collagen metastatic lesions. (a) Numbers of mice with metastasis per group. Note that all treated wild-type (WT) tumor mice developed metastatic lesions versus one tumor mouse expressing the polyoma virus antigen and heterozygote for the col1a1 mutation (COL) (p < 0.05). Representative images of lungs with corresponding metastasis in the WT control group (b), WT anti-Ly6G treated group (c), COL control group (d), and COL anti-Ly6G-treated group (e). Scale bar 2 mm (whole lung image) and 250 μm (metastatic lesion image). f Quantification of the number of metastatic lesions found in each mouse (n = 5–6 per group)