STUDY I | STUDY II | STUDY I vs. STUDY II | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene symbol | R | p value | Geometric mean of B/A | 95 % CI | R | p value | Geometric mean of S/D | 95 % CI | Z value | p value (2 tail) | ||
BAG1 | 0.713 | 0.0001 | 0.971 | 0.946-0.996 | 0.734 | <0.0001 | 1.043 | 0.984-1.106 | -0.17 | 0.865 | ||
MKi67 | 0.354 | 0.0978 | 1.009 | 0.962-1.058 | 0.522 | <0.0001 | 0.977 | 0.930-1.027 | -0.8 | 0.4237 | ||
MAPT | 0.847 | <0.0001 | 0.806 | 0.692-0.938 | 0.811 | <0.0001 | 1.108 | 0.965-1.273 | 0.44 | 0.6599 | ||
PGR | 0.522 | 0.0106 | 1.093 | 0.946-1.263 | 0.824 | <0.0001 | 0.978 | 0.894-1.070 | -2.25 | 0.0244 | ||
SNAI2 | 0.430 | 0.0408 | 0.897 | 0.790-1.018 | 0.481 | 0.0002 | 0.940 | 0.838-1.054 | -0.25 | 0.8026 | ||
Genes that significantly changed in Jeselsohn et al. (2013) [6] | (a) immune related | IGFBP2 | 0.583 | 0.0035 | 1.051 | 0.862-1.282 | 0.784 | <0.0001 | 1.136 | 1.031-1.251 | -1.48 | 0.1389 |
IL6 | 0.712 | 0.0001 | 1.108 | 1.003-1.223 | 0.194 | 0.1525 | 1.167 | 1.079-1.262 | 2.65 | 0.008 | ||
CD68 | 0.412 | 0.0509 | 1.065 | 0.889-1.272 | 0.464 | 0.0003 | 1.099 | 0.985-1.226 | -0.25 | 0.8026 | ||
CD14 | 0.553 | 0.0062 | 1.047 | 0.905-1.211 | 0.355 | 0.0074 | 1.017 | 0.901-1.148 | 0.96 | 0.3371 | ||
CD52 | 0.755 | <0.0001 | 1.085 | 0.923-1.276 | 0.436 | 0.0008 | 1.038 | 0.876-1.230 | 1.97 | 0.0488 | ||
CD44 | 0.458 | 0.0278 | 0.927 | 0.788-1.091 | 0.816 | <0.0001 | 0.952 | 0.890-1.019 | -2.48 | 0.0131 | ||
PPARG | 0.315 | 0.1438 | 0.806 | 0.608-1.068 | 0.343 | 0.0096 | 0.993 | 0.870-1.132 | -0.12 | 0.9045 | ||
ADM | 0.476 | 0.0217 | 0.931 | 0.720-1.204 | 0.544 | <0.0001 | 1.122 | 0.964-1.306 | -0.35 | 0.7263 | ||
VEGFA | 0.653 | 0.0007 | 1.043 | 0.967-1.124 | 0.647 | <0.0001 | 0.991 | 0.930-1.055 | 0.04 | 0.9681 | ||
(b) non-immune related | CENPF | 0.781 | <0.0001 | 1.039 | 0.913-1.183 | 0.729 | <0.0001 | 1.062 | 0.959-1.176 | 0.46 | 0.6455 | |
MYC | 0.509 | 0.0132 | 1.076 | 0.897-1.292 | 0.65 | <0.0001 | 1.439 | 1.241-1.668 | -0.82 | 0.4122 | ||
CCNB1 | 0.413 | 0.0501 | 0.976 | 0.883-1.078 | 0.469 | 0.0003 | 1.010 | 0.919-1.107 | -0.27 | 0.7872 | ||
MAP1LC3B | 0.598 | 0.0026 | 0.957 | 0.882-1.038 | 0.809 | <0.0001 | 0.971 | 0.933-1.010 | -1.65 | 0.099 | ||
SNAI1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |