Fig. 1

Diet-induced obese phenotype in wild-type (WT), cortistatin (CORT)-knockout (KO) and somatostatin (SST)-KO mice. a Growth curves (represented as body weight over time of high-fat (HF) diet feeding, starting at 8 week of age). D indicates effect of HF diet analyzed by two-way analysis of variance. b Glucose (mg/dL) and leptin levels (ng/mL) at the day of sacrifice (23–43/group). c Fat mass, lean mass and free water percentages (close to the day of sacrifice; n = 10–16/group). Values are mean ± standard error of the mean: *p <0.05, **p <0.01, ***p <0.001 for significant differences between groups analyzed by the Fisher, Bonferroni or Mann–Whitney post-hoc test