From: Genetic predisposition to ductal carcinoma in situ of the breast
Single nucleotide polymorphism | rs12631593 | rs13236351 | rs73179023 |
---|---|---|---|
Chromosome | 3 | 7 | 22 |
Position | 60701884 | 97772513 | 43424477 |
Locus | FHIT | LMTK2 | PACSIN2:TTLL1 |
Minor allele frequency | 0.11 | 0.032 | 0.13 |
ICICLE DCIS phase I | Â | Â | |
Odds ratio (95Â % CI) | 1.15 (1.04, 1.28) | 1.31 (1.10, 1.56) | 0.83 (0.75, 0.91) |
P | 0.0088 | 0.0029 | 0.00020 |
BCAC DCIS | Â | Â | |
Odds ratio (95Â % CI) | 1.25 (1.14, 1.36) | 1.3 (1.12, 1.51) | 0.86 (0.79, 0.94) |
P | 1.0 × 10-6 | 0.00060 | 0.0012 |
Meta-analysis phase I | Â | Â | |
Odds ratio (95Â % CI) | 1.21 (1.13, 1.29) | 1.3 (1.16, 1.46) | 0.85 (0.79, 0.90) |
P | 5.5 × 10-8 | 5.7 × 10-6 | 1.1 × 10-6 |
Phase II DCIS | Â | Â | |
Odds ratio (95Â % CI) | 0.93 (0.76, 1.14) | 0.91 (0.63, 1.31) | 0.95 (0.78, 1.15) |
P | 0.49 | 0.61 | 0.57 |
Meta-analysis phase II | Â | Â | |
Odds ratio (95Â % CI) | 1.18 (1.10, 1.25) | 1.26 (1.13, 1.41) | 0.86 (0.80, 0.91) |
P | 7.8 × 10-7 | 2.9 × 10-5 | 1.7 × 10-6 |
BCAC IDC | Â | Â | |
Odds ratio (95Â % CI) | 1.01 (0.97, 1.05) | 1.05 (0.99, 1.13) | 0.97 (0.93, 1.00) |
P | 0.54 | 0.13 | 0.060 |
Case-only | Â | Â | |
DCIS vs IDC P-Het | 0.0048 | 0.17 | 0.0099 |