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Table 2 Overall classification, estrogen receptor (ER)-positive classification, ER-negative classification and classification using the MammaPrint profile

From: Long non-coding RNA expression profiles predict metastasis in lymph node-negative breast cancer independently of traditional prognostic markers

Profile

Number of samples (metastasis/non-metastasis)

Sensitivity (true positive)

Specificity (true negative)

Accuracy a

P b

LncRNA classification

Overall classification

82/82

90 (74)

65 (53)

77

7.3e-14

ER-positive classification

55/55

91 (50)

64 (35)

77

1.1e-9

ER-negative classification

17/17

94 (16)

0 (0)

47

0.50

MammaPrint classification

     

All samples

82/82

90 (74)

22 (18)

56

0.03

ER-positive samples

55/55

91 (50)

55 (30)

73

1.9e-7

ER-negative samples

17/17

94 (16)

0 (0)

47

0.50

  1. aMean of sensitivity and specificity. bFisher’s exact test, one-tailed. Classification performances were assessed by leave one pair out cross-validation with a threshold that resulted in ≥90% sensitivity and maximized the specificity.