Gene | Abbreviation | Function | Reference |
---|---|---|---|
B-cell CLL/lymphoma 2 | BCL2 | Anti-apoptotic | [37] |
Dachshund1 | DACH1 | • Anti-apoptotic | |
• Inhibitor of estrogen signaling | |||
• Cell cycle progression | |||
• Inhibitor of breast cancer stem cells | |||
• Inhibitor of tumor growth and metastasis | |||
Thrombospondin, type I domain containing 4 | THSD4 | May promote matrix assembly | [41] |
Solute carrier organic anion transporter family, member 5A1 | SLCO5A1 | Nutrients (possibly hormones) uptake | [44] |
Growth regulation by estrogen in breast cancer 1 | GREB1 | Estrogen induced breast cancer cells growth/ proliferation | [45] |
Brain-enriched guanylate kinase-associated homolog | BEGAIN | Chromosome segregation | [46] |
Centrosomal protein 70 kDa | CEP70 | • Mitotic spindle assembly | |
• Angiogenesis | |||
Rho-associated, coiled-coil containing protein kinase | ROCK1 | Serine/threonine kinase | |
• Focal adhesion | |||
• Cancer invasion/ metastasis | |||
• Angiogenesis | |||
• Apoptotic membrane blebbing | |||
SUMO1/sentrin specific peptidase 5 | SENP5 | SUMO specific protease | |
• Cell division | |||
• Proliferation | |||
Kinesin family member 16B | KIF16B | Endosome transport and receptor recycling and degradation | |
• FGF/EGF signal transduction | |||
Potassium channel tetramerisation domain containing 2 | KCTD2 | Ion transport | [57] |
• Upregulated in liver metastasis | |||
ATP-dependent DNA helicase homolog | HFM1 | • Putative DNA helicase | [58] |
• Susceptibility to soft-tissue sarcoma | |||
• Extensive tumor aneuploidy | |||
Bone morphogenetic protein 2 | BMP2 | • TGF-β receptor antagonist | |
• Cancer invasion/migration | |||
• Cancer proliferation | |||
• Tumor angiogenesis | |||
• Hormone independence | |||
v-erb-a erythroblastic leukemia viral oncogene homolog 4 | ERBB4 (HER4) | • EGF receptor | |
• Mammary gland differentiation | |||
• Apoptosis | |||
• Cell cycle and proliferation arrest in breast cancer |