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Figure 3 | Breast Cancer Research

Figure 3

From: Imaging in situ breast carcinoma (with or without an invasive component) with technetium-99m pentavalent dimercaptosuccinic acid and technetium-99m 2-methoxy isobutyl isonitrile scintimammography

Figure 3

A 6-cm infiltrating ductal carcinoma, grade 2, with coexistent 5-cm ductal carcinoma in situ, comedo type, of the left breast (patient 1). (a) Mammography, medio-lateral projection. Multinodular opacity with abnormal radiating spicules and clustered microcalcifications (transparent arrow) behind the nipple. (b) Scintimammography, left lateral projection: 99mTc-Sestamibi (99mTc-MIBI) at 10 min and 65 min (upper row, i-ii); 99mTc-(V)DMSA at 15 min and 60 min (bottom row, iii-iv). Increased bifocal 99mTc-Sestamibi uptake (arrowheads) behind the nipple, clearly defining the invasive component of the tumor. Focal 99mTc-(V)DMSA accumulation in the same area (arrowhead), with additional diffuse uptake (arrow) extending inferiorly, more prominent at 60 min and corresponding to the in situ tumor component. No diffuse pattern is imaged with 99mTc-Sestamibi. (c) Scintimammography, left lateral projection: 99mTc-(V)DMSA at 60 min (same as (b) iv), with regions of interest (ROIs) drawn. ROI selection for diffuse uptake with each tracer is based on the comparison between early and late images (see text).

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Breast Cancer Research

ISSN: 1465-542X

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