Figure 3

In vivo detection of solitary mammary carcinoma cells in murine experimental metastasis model. (a) Solitary murine mammary carcinoma (D2.OR) cells (→), fluorescently labelled, are present within normal liver tissue 11 weeks after intravenous injection to target the liver. In close proximity to the cells is a fluorescent 'accounting' microsphere (➢), approximately 10 μm in diameter. The image was obtained by IVVM using epifluorescence plus transillumination. (b) Similar solitary mammary carcinoma cell (→ ; ~ 10-15 μm in diameter) in murine liver, 11 weeks after injection, detected by haematoxylin and eosin staining.