Table 1 Genes previously reported to be regulated by transforming growth factor beta (TGF-β)

Cellular communication

Cell cycle regulator

   Platelet-derived growth factor

No

Up**

Up***

   CDK2 interacting protein (CINP)

Down*

No

Down*

   Fibroblast growth factor regulated

Up**

Up***

Up***

   Cyclin D₂

No

Down*

Down*

   Cadherin 1 (Cdh1)

No

Down*

No

   Cyclin D₃

Up*

No

No

Signal transduction

   CDK9

Up*

Up**

Up*

   Nfkb inducing kinase

Up**

No

No

   Cdk4

Down*

No

No

   RhoB

Up***

Up***

Up**

   Cyclin A₂

Down*

No

Down*

   Serine/threonine kinase 25

No

Up*

No

   Cyclin B₁

No

No

Down**

   Integrin β4

No

Up**

No

   Cyclin B₂

Down*

No

Down*

   Bmp-1

No

Up*

Up*

   Cdc25a

No

Up*

No

   Janus kinase 2 (Jak2)

No

No

Up*

   Cyclin H

No

No

Down*

   Integrin α3A

No

No

Up*

Cancer

   Integrin β1

No

Up*

Up**

   c-myc

Down**

Down*

No

   Integrin-linked kinase (Ilk)

No

Up*

Up*

   Akt

Up**

No

No

   Integrin β5

Up*

Up**

Up***

   GRO1 oncogene

Down**

Down**

Down**

   Tyrosine phosphatase PTPT9

No

Up*

Up*

   Jun oncogene

Up**

No

Up*

   Ephrin-A1 (EFNA1)

Up*

No

No

   E2 oncogene (Ets1)

Up**

Up**

Up*

   BMP-6

No

Up*

Up**

Transport

   TGF-β1-induced transcript

Up*

Up**

Up***

   Glucose transport protein

Up*

No

No

   Colony stimulating factor 1

Up**

Up**

Up***

Ubiquitins and elongation factors

Intracellular components

   Elongation factor 2 (ef-2)

No

Up**

Up**

   TG interacting factor (Tgif)

Up*

Up**

Up**

   Ubiquitin conjugating enzyme

Up*

Up*

Up*

   α-actinin

No

Up**

Up**

Enzyme

   β-tropomyosin 2

No

Up*

Up***

   Glutathione S-transferase

Down*

Down*

Down*

   Catenin src (Catns)

No

Up*

Up*

   Protein tyrosine phosphatase

Up*

No

No

Extracellular components

   Protease serine 15 (PRSS15)

Up*

Up*

No

   α1 type IV collagen

No

No

Up*

   Aldose reductase

No

Up**

Up**

   Fibronectin

No

Up*

Up***

   Disulfide isomerase (ERp59)

No

Up*

No

Nucleic acid binding

   Casein kinase II (Csnk2a2)

No

Up*

No

   Helix-loop-helix DNA binding (Id)

Up***

Down***

Down***

   Ornithine decarboxylase

No

Up**

Up**

   Inhibitor of DNA binding (Idb3)

No

Down*

Down*

   RNA polymerase II

No

No

Up*

   Translation initiation factor 2

No

No

Up*

   Bruton's tyrosine kinase (Btk)

No

Up*

Up*

   Id2

No

Down*

Down*

   Cytochrome b-5 reductase (DIA1)

No

No

Up*