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Table 1 Known or suspected breast cancer genes

From: How many more breast cancer predisposition genes are there?

   

Cumulative risk by age†

Contribution to

Gene

Location

Allele frequency*

50 years (%)

70 years (%)

Breast cancer (%)

Familial risk (%)

BRCA1

17q

0.0005-0.002

50

70‡

1-2

8

BRCA2

13q

0.0005-0.002

30

70‡

1-2

8

TP53

17p

0.0001

~50

 

<1

<1

PTEN

10q

<0.0001

~30?

 

<<1

<1

ATM

11q

0.003

6

18

2

2

HRAS1

11q

0.06

3

10

9

4

  1. *Plausible estimate for large outbred populations.†In the absence of other causes of death; these figures areintended as a guide only. ‡Some studies suggest lower risks for BRCA1 and BRCA2
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Breast Cancer Research

ISSN: 1465-542X

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