Figure 1From: Tyrosine kinase signalling in breast cancer: Epidermal growth factor receptor - convergence point for signal integration and diversificationEGFR transactivation by GPCRs and cytokine receptors. Various signalling stimuli induce EGFR tyrosine phosphorylation to activate different downstream signalling pathways. Apart from the activation of the classical Ras-MAP kinase pathway, GPCR-EGFR cross-talk is critical for G-protein-mediated stress fibre formation, ion channel modulation or PI-3K-stimulated phospholipid turnover. In contrast to cytokine-induced EGFR tyrosine phosphorylation by janus kinase (Jak)2, GPCR-induced EGFR transactivation is dependent on the intrinsic kinase activity of the receptor, and several cytoplasmic mediators have been controversially discussed in the literature.Back to article page