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Table 6 Top canonical pathways of 3, 4, and 10 weeks on diet and tumor sample groups

From: Pubertal high fat diet: effects on mammary cancer development

qPCR dataset

Ingenuity canonical pathways

B-H-adjusted P-value

Ratio

Molecules

3 weeks

Communication between Innate and Adaptive Immune Cells

9.11E-03

2/109

CCL3L1/CCL3L3, IL4

Granulocyte Adhesion and Diapedesisa

9.33E-03a

2/175a

CCL3L1/CCL3L3, CCL24

Agranulocyte Adhesion and Diapedesisa

9.33E-03a

2/186a

CCL3L1/CCL3L3, CCL24

4 weeks

Human Embryonic Stem Cell Pluripotency

1.44E-04

3/156

BDNF, FZD5, LEFTY2

Mouse Embryonic Stem Cell Pluripotency

4.07E-03

2/99

LIF, FZD5

Role of NANOG in Mammalian Embryonic Stem Cell Pluripotencya

4.07E-03a

2/114a

LIF, FZD5

Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis

1.20E-02

2/238

TNFSF11, FZD5

Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritisa

1.83E-02a

2/332a

TNFSF11, FZD5

10 weeks

Granulocyte Adhesion and Diapedesisa

5.66E-09a

8/166a

IL1A, CXCR2, CCL17, CCL20, IL1B, CCL22, CCL19, CCL1

Agranulocyte Adhesion and Diapedesisa

5.66E-09a

8/176a

IL1A, CXCR2, CCL17, CCL20, IL1B, CCL22, CCL19, CCL1

Hepatic Fibrosis / Hepatic Stellate Cell Activation

1.55E-06

6/140

VEGFA, IL1A, TGFB1, TGFA, IL1B, PGF

Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

3.24E-06

5/86

IL1A, IL2, TGFB1, LTA, IL1B

Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritisa

3.32E-06a

7/311a

VEGFA, IL1A, TGFB1, LTA, IL1B, IL7, PGF

Tumor

Molecular Mechanisms of Cancer

7.10E-07

7/378

TP53, CCND2, APAF1, BMP7, BRCA1, CTNNB1, BMP10

p53 Signaling

7.10E-07

5/96

TP53, CCND2, APAF1, BRCA1, CTNNB1

Basal Cell Carcinoma Signaling

1.27E-05

4/73

TP53, BMP7, CTNNB1, BMP10

GADD45 Signaling

1.43E-05

3/22

TP53, CCND2, BRCA1

 

Role of NANOG in Mammalian Embryonic Stem Cell Pluripotencya

4.54E-05a

4/114a

TP53, BMP7, CTNNB1, BMP10

  1. aPathways that are common between groups, with 10 weeks on diet, and tumor groups having an increased number of pathway molecules from 3 and 4 weeks on diet. B-H, Benjamini-Hochberg.