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Figure 3 | Breast Cancer Research

Figure 3

From: The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials

Figure 3

Breast cancer survival and distant recurrence-free survival in relation to high S6K2 and/or 4EBP1 mRNA in four cohorts. Kaplan–Meier curves and multivariate Cox regression of breast cancer survival (BCS) and, when available, of distant recurrence-free survival (DRFS) in relation to high p70 ribosomal S6 kinase 2 (S6K2) and/or 4E-binding protein 1 (4EBP1) mRNA in four cohorts: (a) Stockholm 2, (b) van de Vijver, (c) Uppsala, and (d) Karolinska. The variable S6K2 and/or 4EBP1 was defined in two groups as highest quartile mRNA expression of: neither S6K2 nor 4EBP1 (=0), or of S6K2 and/or 4EBP1 (=1). The Cox analysis also included the following variables: adjuvant chemotherapy treatment, endocrine treatment, lymph node status, tumour size (with exception of van de Vijver), and oestrogen receptor alpha status. CI, confidence interval; HR, hazard ratio.

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Breast Cancer Research

ISSN: 1465-542X

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