| | Univariate | Adjusted |
---|
| n | Beta | SE | Pwald | Ptrend | Pnptrend | Beta | SE | Pwald | Ptrend |
---|
PMD change (continuous)*
|
EM | 122 | 0.00 | Reference | 0.053 | 0.074 | 0.00 | Reference | 0.11 |
hetEM/IM | 136 | 1.47 | 0.78 | 0.06 | | | 0.87 | 0.67 | 0.19 | |
PM | 20 | 1.89 | 1.51 | 0.21 | | | 1.61 | 1.29 | 0.21 | |
Adjusted R2 | | | | |
0.010
| | | | | 0.281 |
Baseline PMD†
|
EM | 122 | 0.00 | Reference | 0.389 | 0.301 | 0.00 | Reference | 0.771 |
hetEM/IM | 136 | -0.24 | 0.17 | 0.16 | | | -0.17 | 0.15 | 0.29 | |
PM | 20 | 0.00 | 0.33 | 1.00 | | | 0.11 | 0.30 | 0.72 | |
Adjusted R2 | | | | | 0.001 | | | | | 0.162 |
Follow-up PMD†
|
EM | 122 | 0.00 | Reference | 0.831 | 0.999 | 0.00 | Reference | 0.413 |
hetEM/IM | 136 | -0.07 | 0.15 | 0.64 | | | -0.02 | 0.14 | 0.90 | |
PM | 20 | 0.23 | 0.30 | 0.44 | | | 0.31 | 0.28 | 0.27 | |
Adjusted R2 | | | | | -0.003 | | | | | 0.100 |
- Results of linear regression analyses treating the absolute difference between follow-up and baseline values in percent mammographic density (PMD) as a continuous variable, and PMD at baseline and follow-up separately. PMD at baseline or follow-up was square-root transformed. *Adjusted for baseline percent mammographic density (PMD), age at baseline (years), and body mass index at baseline (kg/m2). †Adjusted for all of the above except for baseline PMD. SE, standard error; Pwald, P value from Wald tests; Ptrend, P value from Wald tests treating genotypes (0, 1, 2) as a continuous variable; Pnptrend, P value from Cuzick’s test for trend; EM, extensive metabolizer; hetEM/IM, heterozygous extensive/intermediate; PM, poor metabolizer; adjusted R2, adjusted R2 statistic.