From: PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer
 | 4EBP1 | pS6 | pAKT | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Cytoplasmic | Nuclear | Cytoplasmic | Nuclear | ||||||||
 | Present | Absent | P -value | Present | Absent | P -value | High | Low | P -value | High | Low | P -value |
PIK3CA Mutation | 0 | 6 | Â | 0 | 6 | Â | 5 | 1 | Â | 2 | 4 | Â |
PIK3CA Wild-Type | 31 | 19 | 0.006 | 29 | 21 | 0.009 | 16 | 34 | 0.024 | 19 | 31 | 1.000 |
Carrier mutation status | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   BRCA1 | 1 | 2 | 0.581 | 1 | 2 | 0.605 | 1 | 2 | 1.000 | 0 | 3 | 0.284 |
   BRCA2 | 15 | 10 | 0.596 | 17 | 8 | 0.035 | 9 | 16 | 0.582 | 10 | 15 | 0.786 |
   BRCAX | 15 | 13 | 0.456 | 11 | 19 | 0.018 | 11 | 17 | 1.000 | 11 | 17 | 1.000 |
Age - mean (years) | 60.3 | 64.5 | 0.240 | 59.1 | 65.3 | 0.078 | 63.4 | 61.4 | 0.503 | 62.0 | 62.2 | 0.940 |
Primary tumour size (mm) | 20.3 | 17.2 | 0.169 | 19.5 | 18.3 | 0.589 | 17.21 | 20.03 | 0.312 | 20.05 | 18.25 | 0.437 |
Histological type | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Invasive carcinoma - no special type (IC - NST) | 21 | 19 | 0.563 | 22 | 19 | 0.766 | 13 | 28 | 0.212 | 15 | 26 | 1.000 |
   IC-NST with micropapillary areas | 6 | 3 | 0.716 | 3 | 6 | 0.288 | 6 | 3 | 0.066 | 3 | 6 | 1.000 |
   Invasive Papillary Carcinoma | 2 | 2 | 1.000 | 3 | 1 | 0.612 | 2 | 2 | 0.626 | 2 | 2 | 0.626 |
   Invasive Lobular Carcinoma | 2 | 1 | 1.000 | 1 | 1 | 1.000 | 0 | 2 | 0.523 | 1 | 1 | 1.000 |
Tumour Grade | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   1 | 2 | 1 | 1.000 | 2 | 1 | 1.000 | 2 | 1 | 0.549 | 1 | 2 | 1.000 |
   2 | 16 | 13 | 1.000 | 16 | 13 | 0.789 | 9 | 20 | 0.409 | 11 | 18 | 1.000 |
   3 | 13 | 11 | 1.000 | 11 | 13 | 0.590 | 10 | 14 | 0.591 | 9 | 15 | 1.000 |
LVI | 40.7% | 36.0% | 0.781 | 28.0% | 48.2% | 0.163 | 31.8% | 43.3% | 0.565 | 33.3% | 41.9% | 0.780 |
PNI | 51.7% | 45.8% | 0.575 | 40.7% | 57.6% | 0.436 | 36.4% | 58.1% | 0.166 | 33.3% | 59.0% | 0.093 |
Intrinsic subtype | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Luminal | 26 | 24 | 0.210 | 24 | 26 | 0.195 | 17 | 33 | 0.183 | 20 | 30 | 0.393 |
   HER2 | 4 | 1 | 0.367 | 4 | 1 | 0.353 | 3 | 2 | 0.352 | 1 | 4 | 0.640 |
   Basal | 1 | 0 | 1.000 | 1 | 0 | 1.000 | 1 | 0 | 0.375 | 0 | 1 | 1.000 |
   Null | 0 | 0 | 1.000 | 0 | 0 | 1.000 | 0 | 0 | 1.000 | 0 | 0 | 1.000 |