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Table 4 Sensitivity and specificity of the IHC signatures of MA tumors in ER(-) subgroup.

From: Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15

IHC biomarker

Sensitivity (95% CI)

Specificity (95% CI)

AUC

AR(+)

58% (44 to 72)

100% (75 to 99)

0.792 (0.726 to 0.859)

AR(+) and FOXA1(+)

57% (43 to 71)

100% (75 to 99)

0.787 (0.721 to 0.853)

HER2(3+) or GCDFP15(+)

94% (85 to 99)

100% (75 to 99)

0.972 (0.942 to 0.999)

  1. AR, androgen receptor; ER, estrogen receptor; HER2, Human Epidermal Growth Factor Receptor 2; IHC, immunohistochemistry; MA, molecular apocrine.
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Breast Cancer Research

ISSN: 1465-542X

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