Figure 5

Effects of celecoxib treatment on Ki-67 protein expression. (A) Examples of immunohistochemical staining of nuclear Ki-67 protein on breast cancer tissues yielding a high score (left) and low score (right). Scale bar = 100 μm. (B) Shown are the Ki-67 scores from individual patients in the control arm (plot on left-hand side) and treatment arm (plot on right-hand side). Geometric means in the control group were statistically not different (P = 0.384), while the geometric mean after celecoxib treatment was significantly reduced (P = 0.019). Also, the change of the means between both groups was significantly greater in the celecoxib-treated group (P = 0.029).