From: The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer
 | Cyclin D1 - n (%) | Cyclin D1 + n (%) | P-value | Cdk4 - n (%) | Cdk4 + n (%) | P-value | P16 - n (%) | p16 + n (%) | P-value |
---|---|---|---|---|---|---|---|---|---|
Tumour | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   T1 | 21 (52.5) | 41 (73.2) |  | 14 (56.0) | 39 (65.0) |  | 27 (64.3) | 32 (62.7) |  |
   T2 | 13 (32.5) | 12 (21.4) |  | 10 (40.0) | 14 (23.4) |  | 10 (23.8) | 15 (29.4) |  |
   T3 | 3 (7.5) | 3 (5.4) |  | 1 (4.0) | 5 (8.3) |  | 2 (4.8) | 4 (7.8) |  |
   T4 | 3 (7.5) | 0 (0.0) |  | 0 (0.0) | 2 (3.3) |  | 3 (7.1) | 0 (0.0) |  |
 |  |  | 0.066 |  |  | 0.431 |  |  | 0.273 |
Nodus | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Negative | 20 (51.3) | 34 (61.8) |  | 15 (65.2) | 34 (56.7) |  | 26 (61.9) | 29 (59.2) |  |
   Positive | 19 (48.7) | 21 (38.2) |  | 8 (34.8) | 26 (43.3) |  | 16 (38.1) | 20 (40.8) |  |
 |  |  | 0.309 |  |  | 0.478 |  |  | 0.791 |
Grade | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   I | 9 (22.5) | 20 (35.7) |  | 11 (44.0) | 14 (23.3) |  | 11 (26.2) | 17 (33.3) |  |
   II | 10 (25.0) | 23 (41.1) |  | 6 (24.0) | 22 (36.7) |  | 14 (33.3) | 16 (31.4) |  |
   III | 21 (52.5) | 13 (23.2) |  | 8 (32.0) | 24 (40.0) |  | 17 (42.5) | 18(35.3) |  |
 |  |  | 0.013* |  |  | 0.156 |  |  | 0.747 |
Estrogen receptor (ER) | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Negative | 18 (45.0) | 3 (5.4) |  | 6 (24.0) | 14 (23.3) |  | 10 (23.8) | 12 (23.5) |  |
   Positive | 22 (55.0) | 53 (96.6) |  | 19 (76.0) | 46 (76.7) |  | 32 (76.2) | 39 (76,5) |  |
 |  |  | 0.000*** |  |  | 0.947 |  |  | 0.975 |
Progesterone receptor (PR) | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Negative | 18 (45.0) | 13 (23.3) |  | 8 (32.0) | 22 (36.7) |  | 15 (35.7) | 18 (35.3) |  |
   Positive | 22 (55.00) | 43 (76.8) |  | 17 (68.0) | 38 (63.3) |  | 27 (64.3) | 33 (64.7) |  |
 |  |  | 0.024* |  |  | 0.682 |  |  | 0.966 |
HER2 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Negative | 30 (75.0) | 48 (85.7) |  | 21 (84.0) | 48 (80.0) |  | 28 (66.7) | 47 (92.2) |  |
   Positive | 10 (25.0) | 8 (14.3) |  | 4 (16.0) | 12 (20.0) |  | 14 (33.3) | 4 (7.8) |  |
 |  |  | 0.185 |  |  | 0.769 |  |  | 0.002** |
Ki67 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Negative | 8 (20.0) | 12 (21.4) |  | 6 (24.0) | 9 (15.0) |  | 8 (19.0) | 10 (19.6) |  |
   + | 10 (25.0) | 24 (42.9) |  | 11 (44.0) | 21 (35.0) |  | 15 (35.7) | 18 (35.3) |  |
   ++ | 7 (17.5) | 13 (23.2) |  | 2 (8.0) | 16 (26.7) |  | 10 (23.8) | 9 (17.6) |  |
   +++ | 15 (37.5) | 7 (12.5) |  | 6 (24.0) | 14 (23.3) |  | 9 (21.4) | 14 (27.5) |  |
 |  |  | 0.031* |  |  | 0.251 |  |  | 0.856 |