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Table 2 Univariate analysis of RFS and OS for hormone receptor-positive breast cancer patients.

From: Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer

Recurrence-free survival

Variable

HR

95% CI

Pvalue

FDR

Translational regulator

    

   p4E-BP1 S65

1.51

1.08-2.11

0.02

0.09

   p4E-BP1 T36/47

1.49

1.05-2.12

0.03

0.09

   4E-BP1

1.66

1.04-2.65

0.04

0.09

   p4E-BP1 T70

1.38

1.00-1.90

0.05

0.10

   pS6 S235/236

1.37

0.81-2.31

0.23

0.27

   pS6 S240/244

1.23

0.83-1.83

0.30

0.29

   eIF4G

1.33

0.77-2.30

0.30

0.30

   Pdcd4

0.81

0.52-1.26

0.34

0.31

   eIF4E

1.12

0.75-1.67

0.58

0.43

   S6

0.96

0.67-1.37

0.82

0.52

   eEF2K

1.04

0.70-1.55

0.83

0.52

   eEF2

0.98

0.59-1.61

0.93

0.55

Age at diagnosis

1.01

0.98-1.04

0.64

 

Nodal Status

    

   Negative

1

   

   Positive

2.789

1.55-5.03

<0.01

 

T Stage

    

   T1

1

   

   T2-4

1.339

0.71-2.52

0.37

 

Overall survival

Variable

HR

95% CI

 

FDR

Translational regulator

    

   Pdcd4

0.62

0.42-0.91

0.0155

0.06

   p4E-BP1 T70

1.30

0.98-1.71

0.0662

0.12

   pS6 S235/236

1.40

0.90-2.18

0.1369

0.14

   eEF2

1.27

0.82-1.95

0.2852

0.15

   4EBP1

1.22

0.78-1.91

0.3801

0.16

   eEF2K

1.15

0.82-1.62

0.4093

0.16

   p4E-BP1 S65

1.15

0.82-1.60

0.4144

0.16

   S6

1.14

0.83-1.55

0.4192

0.16

   pS6 S240/244

1.14

0.81-1.60

0.4484

0.16

   p4E-BP1 T36/47

1.13

0.81-1.56

0.4670

0.16

   eIF4E

0.94

0.68-1.31

0.7162

0.22

   eIF4G

0.98

0.61-1.55

0.9142

0.27

Age at diagnosis

1.05

1.03-1.08

<0.01

 

Nodal status

    

   Negative

1

   

   Positive

2.05

1.25-3.35

<0.01

 

T Stage

    

   T1

1

   

   T2-T4

1.36

0.79-2.34

0.26

 
  1. CI, confidence interval; FDR, false discovery rate; HR, hazard ratio.
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Breast Cancer Research

ISSN: 1465-542X

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