Figure 5
From: Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland
Comparison of normal mammary cell populations with breast cancer molecular subtypes. Aldehyde dehydrogenase-positive (ALDH+) and oestrogen receptor-negative (ER-) progenitors have a gene expression profile similar to basal-like breast cancers. (A) Boxplots depicting correlation scores of ALDH+ (A+), ALDH- (A-), ERBB3- (E-), nonclonogenic luminal (NCL; L), basal (B) and stromal (S) cell subtypes, stratified according to breast cancer intrinsic subtype. (B) Results of the decision tree nearest-neighbour classifier showing the relation between cell-type-specific signatures and those defining the breast cancer intrinsic subtypes. The ALDH+ subpopulation scores the highest with regards to similarity to the basal-like breast cancer signature. (C) Heatmap of genes (red, high expression; green, low expression) of the top 5% differentially expressed genes in the four types of mouse mammary epithelial cells. Samples are clustered on the basis of cell type. (D) Boxplots depicting correlation scores of intrinsic subtypes stratified according to mouse mammary cell subtype.