Figure 7
From: Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions
Case #84: classic lobular carcinoma in situ and associated low-grade ductal carcinoma in situ. (A) Terminal duct lobular units expanded by classic lobular carcinoma in situ (LCIS; H & E, 200×). (B) Lack of membranous E-cadherin immunoreactivity on LCIS cells. The residual luminal cells show strong membrane staining (E-cadherin, 100×). (C) Low-grade ductal carcinoma in situ (DCIS) showing a prominent cribriform pattern (H & E, 100×). (D) Strong, uniform membrane staining with E-cadherin on DCIS cells (E-cadherin, 100×).