Figure 2
From: Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions
Examples of genome-wide segmentation patterns of tumor pairs. (A) Case #122. (B) Case #84. (C) Case #93. Each dot represents a log ratio; that is, allelic copy number relative to the reference normal value on log scale. In the absence of gains or losses, this should be zero. Known or suspected germline copy number variations were filtered out prior to constructing these plots. Regions of significant gain used in clonality comparison are highlighted in blue, while regions of loss are highlighted in red. DCIS, ductal carcinoma in situ; ILC, invasive lobular carcinoma; LCIS, lobular carcinoma in situ.