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Table 5 Predictive impact of mammographic density reduction ratio (MDRR) on recurrence-free survival

From: Breast density change as a predictive surrogate for response to adjuvant endocrine therapy in hormone receptor positive breast cancer

Variable

Hazard ratio

95% Confidence interval

P-value

Age, yr (continuous)

0.99

0.97-1.02

0.600

MDRR (%)*

   

≥ 25%

1.00

Referent

0.078

10%-25%

1.37

0.73-2.58

0.327

0%-10%

2.09

1.07-4.06

0.030

< 0% (increased)

2.17

1.08-4.35

0.030

Size, cm (continuous)

1.19

1.05-1.35

0.007

Lymph node positive

1.98

1.18-3.34

0.010

High histologic grade

1.34

0.80-2.24

0.261

Chemotherapy done

0.79

0.39-1.60

0.519

Ki-67 ≥ 10%

0.60

0.33-0.94

0.029

  1. Cox proportional hazard regression model for recurrence-free survival. Risk of recurrence was analyzed using the group with the greatest reduction (MDRR ≥ 25%) as the reference. *MDRR = (pre-treatment MD - post-treatment MD) × 100/pre-treatment MD.
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Breast Cancer Research

ISSN: 1465-542X

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