Table 1 Genes in the MS-MLPA kit and frequencies of promoter hypermethylation in male breast cancer patients
Gene | Hypermethylation | Chromosome | Gene name |
|---|---|---|---|
MSH6 | 104 (96%) | 02p16.3 | mutS homologue 6 |
WT1 | 91 (84%) | 11p13 | Wilms tumor 1 |
PAX5 | 85 (79%) | 09p13.2 | Paired box 5 |
CDH13 | 83 (77%) | 16q24.1 | Cadherin 13, H-cadherin |
GATA5 | 60 (56%) | 20q13.33 | GATA binding protein 5 |
PAX6 | 57 (53%) | 11p13 | Paired box 6 |
GSTP1 | 47 (44%) | 11q13.1 | Glutathione S-transferase p1 |
THBS1 | 21 (19%) | 15q14 | Thrombospondin 1 |
BRCA2 | 18 (17%) | 13q13.1 | Breast cancer gene 2 |
CD44 | 17 (16%) | 11p13 | CD44 molecule (Indian blood group) |
TP73 | 14 (13%) | 01p36.32 | Tumor protein p73 |
TP53 | 12 (11%) | 17p13.1 | Tumor protein p53 |
ESR1 | 9 (8%) | 06q25.1 | Estrogen receptor 1 |
CADM1 | 9 (8%) | 11q23.2 | Cell adhesion molecule 1 |
MGMT | 8 (7%) | 10q26.3 | O-6-Methylguanine-DNA methyltransferase |
STK11 | 8 (7%) | 19p13.3 | Serine/threonine kinase 11 |
RARB | 5 (5%) | 03p24.2 | Retinoic acid receptor beta |
PTEN | 5 (5%) | 10q23.31 | Phosphatase and tensin homologue |
PYCARD | 5 (5%) | 16p11.2 | PYD and CARD domain containing (TMS1) |
RB1 | 3 (3%) | 13q14.2 | Retinoblastoma 1 |
BRCA1 | 2 (2%) | 17q21.31 | Breast cancer gene 1 |
CDKN2A | 2 (2%) | 09p21.3 | Cyclin-dependent kinase inhibitor 2A (p14-ARF) |
VHL | 2 (2%) | 03p25.3 | von Hippel-Lindau |
ATM | 1 (1%) | 11q22.3 | Ataxia telangiectasia mutated |
CHFR | 1 (1%) | 12q24.33 | Checkpoint with forkhead and ring finger domains |