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Table 6 Multivariate analyses for distant relapse for patients with estrogen receptor-negative disease.

From: Centromere protein-A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor-positive breast cancer

 

TRANSBIG (5 y DRFS)

MDA233 (RCB 0/1)

Variable

HR

95% CI

P-value

HR

95% CI

P-value

Age

0.99

0.92-1.07

0.84

0.93

0.88-0.98

0.01

T stage

0.81

0.29-2.26

0.69

0.06

0.00-0.82

0.035

Nodal status

---

---

---

0.88

0.25-3.10

0.84

Grade

2.18

0.41-11.67

0.36

2.16

0.52-9.00

0.29

ESR1

0.73

0.48-1.10

0.13

0.82

0.58-1.15

0.26

CENP-A

0.49

0.20-1.20

0.12

1.32

0.65-2.66

0.44

Ki-67

0.63

0.24-1.67

0.36

1.01

0.53-1.93

0.97

Her2/neu

0.90

0.69-1.19

0.46

0.97

0.61-1.54

0.91

  1. ESR1 (estrogen receptor alpha), CENP-A (centromere protein-A), Ki-67, and Her2/neu are continuous variables reflecting mRNA levels; HR, Hazard ratio; CI, confidence interval; DRFS, distant-relapse free survival; RCB, residual cancer burden
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Breast Cancer Research

ISSN: 1465-542X

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