Centromere protein-A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor-positive breast cancer

Table 4 Univariate and multivariate analyses for distant relapse at 5 years in patients with estrogen receptor-positive disease in the TRANSBIG dataset.

	Univariate analyses			Multivariate analysis without CENP-A			Multivariate analysis with CENP-A
Variable	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
Age	0.98	0.92-1.05	0.62	1.00	0.93-1.08	0.95	1.01	0.93-1.09	0.89
T stage	1.22	0.47-3.16	0.68	0.82	0.31-2.19	0.70	0.59	0.21-1.67	0.32
Grade	2.70	1.04-7.00	0.04	2.65	0.93-7.55	0.069	1.01	0.33-3.11	0.98
ESR1	1.32	0.87-1.98	0.19	1.63	1.05-2.52	0.025	2.00	1.30-3.08	0.0015
CENP-A	3.30	1.84-5.89	0.000056	---	---	---	10.93	2.86-41.78	0.00047
Ki-67	2.18	1.32-3.60	0.0022	2.83	1.48-5.42	0.0017	1.03	0.58-1.84	0.91
Her2/neu	1.11	0.74-1.66	0.63	1.14	0.79-1.65	0.49	1.10	0.77-1.58	0.60

ESR1 (estrogen receptor alpha), CENP-A (centromere protein-A), Ki-67, and Her2/neu are continuous variables reflecting mRNA levels; HR, hazard ratio; CI, confidence interval; DRFS, distant-relapse free survival; RCB, residual cancer burden

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