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Table 2 Areas under the receiver operating characteristic curves for different combinations of prediction models.

From: Breast cancer risk prediction and individualised screening based on common genetic variation and breast density measurement

    

OLDmodel

NEWmodel

 

OLDmodel

NEWmodel

Controls

Cases

AUC (95%CI)a

P-value AUCb

AUC (95%CI)a

P-value AUCb

P-value ΔAUCc

Swe-Gail

Swe-Gail, PD, BMI

1672

1739

0.569 (0.550 - 0.588)

3.00 × 10-12

0.602 (0.584 - 0.621)

3.85 × 10-25

1.17 × 10-7

Swe-Gail

Swe-Gail, The7

1527

1566

0.548 (0.527 - 0.568)

4.57 × 10-6

0.597 (0.577 - 0.617)

9.98 × 10-21

7.44 × 10-17

Swe-Gail

Swe-Gail, The18

1527

1566

0.548 (0.527 - 0.568)

4.57 × 10-6

0.615 (0.595 - 0.634)

1.96 × 10-28

1.54 × 10-18

Swe-Gail, The7

Swe-Gail, The18

1527

1566

0.597 (0.577 - 0.617)

9.98 × 10-21

0.615 (0.595 - 0.634)

1.96 × 10-28

4.69 × 10-4

Swe-Gail

Swe-Gail, PD, BMI

856

1017

0.552 (0526 - 0.578)

1.09 × 10-4

0.571 (0.545 - 0.597)

1.06 × 10-7

2.23 × 10-7

Swe-Gail

Swe-Gail, PD, BMI, The7

856

1017

0.552 (0526 - 0.578)

1.09 × 10-4

0.604 (0.579 - 0.630)

6.95 × 10-15

1.19 × 10-7

Swe-Gail

Swe-Gail, PD, BMI, The18

856

1017

0.552 (0526 - 0.578)

1.09 × 10-4

0.619 (0.594 - 0.644)

6.16 × 10-19

3.24 × 10-9

Swe-Gail,PD,BMI

Swe-Gail, PD, BMI, The7

856

1017

0.571 (0.545 - 0.597)

1.06 × 10-7

0.604 (0.579 - 0.630)

6.95 × 10-15

9.50 × 10-9

Swe-Gail, PD, BMI

Swe-Gail, PD, BMI, The18

856

1017

0.571 (0.545 - 0.597)

1.06 × 10-7

0.619 (0.594 - 0.644)

6.16 × 10-19

1.93 × 10-9

Swe-Gail, PD, BMI, The7

Swe-Gail, PD, BMI, The18

856

1017

0.604 (0.579 - 0.630)

6.95 × 10-15

0.619 (0.594 - 0.644)

6.16 × 10-19

6.18 × 10-3

  1. a AUC and Confidence Interval (CI) evaluated using Delongs non-parametric estimation.
  2. b Null hypothesis of AUC = 0.5 assessed using Mann-Whitney U test.
  3. c Null hypothesis of ΔAUC = 0 assessed using DeLongs Test.