Table 4 Cumulative effects of associated SNPs and clinical risk factors on the risk of breast cancer in all samples

Counts of risk alleles ^a

0 to 1

187 (11.08)

295 (16.70)

1.00 (ref.)

2

327 (19.37)

408 (23.10)

1.25 (0.98 to 1.60)

7.04E-02

3

472 (27.96)

503 (28.48)

1.48 (1.18 to 1.87)

8.04E-04

4

404 (23.93)

351 (19.88)

1.85 (1.45 to 2.35)

6.03E-07

5

201 (11.91)

152 (8.61)

2.09 (1.56 to 2.79)

6.76E-07

≥ 6

97 (5.75)

57 (3.23)

2.67 (1.81 to 3.93)

6.40E-07

2.27E-12

Counts of risk factors ^b

0 to 2

109 (6.61)

277 (15.79)

1.00 (ref.)

3

203 (12.31)

344 (19.61)

1.54 (1.16 to 2.04)

3.08E-03

4

335 (20.32)

386 (22.01)

2.28 (1.75 to 2.99)

1.54E-09

5

346 (20.98)

377 (21.49)

2.47 (1.89 to 3.23)

4.11E-11

6

338 (20.50)

219 (12.49)

4.19 (3.15 to 5.56)

4.07E-23

≥ 7

318 (19.28)

151 (8.61)

5.61 (4.16 to 7.56)

1.03E-29

3.76E-40

Genetic risk score ^a

0 (< Q25)

349 (20.68)

487 (27.58)

1.00 (ref.)

1(Q25 to Q50)

406 (24.05)

499 (28.26)

1.21 (0.99 to 1.48)

6.96E-02

2 (Q50 to Q75)

436 (25.83)

405 (22.93)

1.57 (1.28 to 1.93)

1.74E-05

3 (≥ Q75)

497 (29.44)

375 (21.23)

1.91 (1.56 to 2.35)

5.60E-10

2.02E-11

0 (< Q25)

167 (10.13)

437 (24.91)

1.00 (ref.)

1 (Q25 to Q50)

332 (20.13)

442 (25.20)

2.01 (1.60 to 2.53)

2.68E-09

2 (Q50 to Q75)

406 (24.62)

438 (24.97)

2.55 (2.03 to 3.20)

6.66E-16

3 (≥ Q75)

744 (45.12)

437 (24.91)

4.73 (3.80 to 5.88)

2.38E-44

2.27E-47