Genotype | Testing Set, TS. (n= 1,779) | Validation Set, VS. (n= 1,881) | Adjusted OR (95% CI)a | P a | Adjusted OR (95% CI)b | P b | Adjusted OR (95% CI)c | P c | ||
---|---|---|---|---|---|---|---|---|---|---|
 | Case (%) (n= 878) | Control (%) (n= 900) | Cases (%) (n= 914) | Controls (%) (n= 967) |  |  |  |  |  |  |
2q35: rs13387042 | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
GG | 627 (72.74) | 695 (77.91) | 712 (78.33) | 773 (80.60) | 1.00 (ref.) | Â | 1.00 (ref.) | Â | 1.00 (ref.) | Â |
GA | 223 (25.87) | 188 (21.08) | 181 (19.91) | 178 (18.56) | 1.29 (1.03 to 1.63) | 0.030 | 1.21 (0.93 to 1.56) | 0.155 | 1.23 (1.04 to 1.46) | 0.018 |
AA | 12 (1.39) | 9 (1.01) | 16 (1.76) | 8 (0.83) | 1.46 (0.60 to 3.54) | 0.407 | 2.56 (1.03 to 6.38) | 0.044 | 1.95 (1.04 to 3.66) | 0.037 |
GA/AA | 235 (27.26) | 197 (22.09) | 197 (21.67) | 186 (19.40) | 1.30 (1.04 to 1.63) | 0.023 | 1.27 (0.99 to 1.63) | 0.064 | 1.26 (1.07 to 1.49) | 0.006 |
A allelic trend (Additive model) | Â | Â | 1.30 (1.05 to 1.62) | 0.017 | 1.21 (0.97 to 1.51) | 0.085 | 1.25 (1.07 to 1.46) | 0.004 | ||
3q24.1: rs2307032 | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
CC | 265 (30.78) | 327 (37.16) | 288 (31.58) | 326 (34.42) | 1.00 (ref.) | Â | 1.00 (ref.) | Â | 1.00 (ref.) | Â |
CT | 436 (50.64) | 398 (45.23) | 429 (47.04) | 464 (49.00) | 1.31 (1.05 to 1.63) | 0.016 | 1.09 (0.87 to 1.37) | 0.459 | 1.20 (1.02 to 1.40) | 0.027 |
TT | 160 (18.58) | 155 (17.61) | 195 (21.38) | 157 (16.58) | 1.27 (0.95 to 1.69) | 0.105 | 1.43 (1.06 to 1.91) | 0.018 | 1.36 (1.11 to 1.66) | 0.003 |
CT/TT | 596 (69.22) | 553 (62.84) | 624 (68.42) | 621 (65.58) | 1.30 (1.06 to 1.60) | 0.014 | 1.18 (0.95 to 1.46) | 0.138 | 1.24 (1.07 to 1.44) | 0.005 |
T allelic trend (Additive model) | Â | Â | 1.11 (0.97 to 1.27) | 0.122 | 1.17 (1.02 to 1.34) | 0.025 | 1.14 (1.04 to 1.26) | 0.006 | ||
6q22.33: rs2180341 | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
AA | 423 (49.76) | 480 (54.55) | 479 (52.64) | 541 (56.53) | 1.00 (ref.) | Â | 1.00 (ref.) | Â | 1.00 (ref.) | Â |
AG | 373 (43.88) | 334 (37.95) | 380 (41.76) | 350 (36.57) | 1.29 (1.05 to 1.59) | 0.016 | 1.26 (1.02 to 1.56) | 0.033 | 1.28 (1.10 to 1.48) | 0.001 |
GG | 54 (6.35) | 66 (7.50) | 51 (5.60) | 66 (6.90) | 0.96 (0.64 to 1.43) | 0.847 | 0.87 (0.57 to 1.32) | 0.505 | 0.93 (0.70 to 1.24) | 0.614 |
AG/GG | 427 (50.24) | 400 (45.45) | 431 (47.36) | 416 (43.47) | 1.24 (1.01 to 1.51) | 0.036 | 1.20 (0.97 to 1.47) | 0.086 | 1.22 (1.06 to 1.40) | 0.006 |
G allelic trend (Additive model) | Â | Â | 1.10 (0.94 to 1.29) | 0.222 | 1.06 (0.90 to 1.24) | 0.496 | 1.08 (0.97 to 1.20) | 0.174 | ||
6q25.1: rs2046210 | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
GG | 290 (33.68) | 387 (43.48) | 292 (32.19) | 380 (39.58) | 1.00 (ref.) | Â | 1.00 (ref.) | Â | 1.00 (ref.) | Â |
GA | 413 (47.97) | 393 (44.16) | 460 (50.72) | 443 (46.15) | 1.46 (1.17 to 1.81) | 6.31 × 10to 4 | 1.38 (1.10 to 1.73) | 4.81 × 10-3 | 1.43 (1.23 to 1.67) | 5.12 × 10-6 |
AA | 158 (18.35) | 110 (12.36) | 155 (17.09) | 137 (14.27) | 2.05 (1.52 to 2.76) | 2.95 × 10-6 | 1.54 (1.13 to 2.09) | 5.76 × 10-3 | 1.79 (1.45 to 2.22) | 7.13 × 10-8 |
GA/AA | 571 (66.32) | 503 (56.52) | 615 (67.81) | 580 (60.42) | 1.59 (1.29 to 1.94) | 8.52 × 10-6 | 1.42 (1.15 to 1.76) | 1.27 × 10-3 | 1.51 (1.31 to 1.75) | 2.40 × 10-8 |
A allelic trend (Additive model) | Â | Â | 1.41 (1.22 to 1.62) | 1.54E-06 | 1.24 (1.08 to 1.43) | 2.27E-03 | 1.33 (1.20 to 1.46) | 1.92E-08 | ||
10q26.13: rs2981582 | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
CC | 362 (41.51) | 420 (46.88) | 370 (41.29) | 464 (48.95) | 1.00 (ref.) | Â | 1.00 (ref.) | Â | 1.00 (ref.) | Â |
CT | 400 (45.87) | 388 (43.30) | 420 (46.88) | 408 (43.04) | 1.25 (1.01 to 1.53) | 3.85 × 10-2 | 1.20 (0.97 to 1.49) | 9.84 × 10-2 | 1.24 (1.07 to 1.44) | 4.40 × 10-3 |
TT | 110 (12.61) | 88 (9.82) | 106 (11.83) | 76 (8.02) | 1.49 (1.07 to 2.08) | 1.76 × 10-2 | 1.82 (1.27 to 2.62) | 1.19 × 10-3 | 1.65 (1.29 to 2.10) | 5.75 × 10-5 |
CT/TT | 510 (58.49) | 476 (53.13) | 526 (58.71) | 484 (51.05) | 1.29 (1.06 to 1.57) | 1.15 × 10-2 | 1.29 (1.05 to 1.59) | 9.84 × 10-2 | 1.31 (1.14 to 1.50) | 1.96 × 10-4 |
T allelic trend (Additive model) | Â | Â | 1.23 (1.07 to 1.42) | 0.005 | 1.30 (1.12-1.51) | 0.0005 | 1.27 (1.15 to 1.41) | 4.89E-06 |