Marker | Category | N (%) | Univariate | Multivariate | ||
---|---|---|---|---|---|---|
 |  |  | Unadjusted Hazard Ratio (95%CI) | P-value (Log-rank) | Adjusted Hazard Ratio (95%CI) | P-value(Wald) |
AF6 | Neg. | 193 (23%) | Â | Â | Â | Â |
 | Pos. | 656 (77%) | 0.86 (0.63 to 1.20) | 0.386 | 0.87 (0.61 to 1.24) | 0.437 |
Angiogenin | Neg. | 71 (7%) | Â | Â | Â | Â |
 | Pos. | 879 (93%) | 1.06 (0.65 to 1.74) | 0.803 | 1.01 (0.59 to 1.75) | 0.967 |
Aurora A | Neg. | 585 68%) | Â | Â | Â | Â |
 | Pos. | 276 (32%) | 1.41 (1.07 to 1.87) | 0.015 | 1.32 (0.98 to 1.79) | 0.070 |
BCL2 | Neg. | 377 (39%) | Â | Â | Â | Â |
 | Pos. | 580 (61%) | 0.60 (0.47 to 0.78) | <.001 | 0.82 (0.60 to 1.12) | 0.217 |
α-Catenin | Neg. | 359 42%) |  |  |  |  |
 | Pos. | 501 (58%) | 0.88 (0.67 to 1.16) | 0.374 | 0.99 (0.73 to 1.34) | 0.927 |
β-Catenin | Neg. | 265 (29%) |  |  |  |  |
 | Pos. | 636 (71%) | 0.83 (0.63 to 1.11) | 0.216 | 0.88 (0.64 to 1.21) | 0.439 |
CAV1 | Neg. | 179 (19%) | Â | Â | Â | Â |
 | Pos. | 778 (81%) | 1.39 (0.96 to 1.99) | 0.077 | 1.16 (0.76 to 1.76) | 0.495 |
CD10 | Neg. | 409 (45%) | Â | Â | Â | Â |
 | Pos. | 508 (55%) | 1.19 (0.91 to 1.55) | 0.199 | 1.20 (0.90 to 1.61) | 0.211 |
CD44 | Neg. | 430 (61%) | Â | Â | Â | Â |
 | Pos. | 280 (39%) | 0.83 (0.62 to 1.14) | 0.264 | 0.90 (0.65 to 1.25) | 0.524 |
CK5/6 | Neg. | 248 (27%) | Â | Â | Â | Â |
 | Pos. | 667 (73%) | 0.88 (0.67 to 1.18) | 0.414 | 0.98 (0.71 to 1.36) | 0.921 |
CK8/18 | Neg. | 22 (2%) | Â | Â | Â | Â |
 | Pos. | 948 (98%) | 0.30 (0.17 to 0.55) | <.001 | 0.54 (0.28 to 1.03) | 0.060 |
CK14 | Neg. | 774 (83%) | Â | Â | Â | Â |
 | Pos. | 158 (17%) | 1.01 (0.71 to 1.42) | 0.974 | 0.81 (0.55 to 1.19) | 0.288 |
Cyclin D1 | Neg. | 316 (33%) | Â | Â | Â | Â |
 | Pos. | 648 (67%) | 0.86 (0.66 to 1.13) | 0.301 | 1.11 (0.81 to 1.51) | 0.526 |
E-Cadherin | Neg. | 128 (13%) | Â | Â | Â | Â |
 | Pos. | 873 (87%) | 1.09 (0.74-1.60) | 0.653 | 0.98 (0.62-1.57) | 0.937 |
EGFR | Neg. | 814 (81%) | Â | Â | Â | Â |
 | Pos. | 185 (19%) | 1.02 (0.74 to 1.41) | 0.895 | 0.72 (0.49 to 1.05) | 0.090 |
ER | Neg. | 283 (26%) | Â | Â | Â | Â |
 | Pos. | 785 (74%) | 0.53 (0.42 to 0.69) | <0.001 | 0.90 (0.47 to 1.71) | 0.744 |
FGFR1 | Neg. | 114 (15%) | Â | Â | Â | Â |
 | Pos. | 626 (85%) | 1.36 (0.86 to 2.14) | 0.189 | 1.60 (0.93 to 2.74) | 0.087 |
FHIT | Neg. | 237 (26%) | Â | Â | Â | Â |
 | Pos. | 672(74%) | 1.03 (0.76 to 1.40) | 0.825 | 1.41 (0.98 to 2.01) | 0.062 |
GATA3 | Neg. | 166 (17%) | Â | Â | Â | Â |
 | Pos. | 816 (83%) | 0.70 (0.52 to 0.96) | 0.027 | 0.83 (0.58 to 1.19) | 0.311 |
HER2 | Neg. | 917 (84%) | Â | Â | Â | Â |
 | Pos. | 175 (16%) | 1.64 (1.23 to 2.19) | <0.001 | 1.12 (0.80 to 1.57) | 0.493 |
Ki67 | Neg. | 661 (70%) | Â | Â | Â | Â |
 | Pos. | 280 (30%) | 1.97 (1.51 to 2.56) | <0.001 | 1.53 (1.12 to 2.08) | 0.007 |
MET | Neg. | 602 (66%) | Â | Â | Â | Â |
 | Pos. | 315 (34%) | 1.26 (0.97 to 1.65) | 0.088 | 1.25 (0.93 to 1.66) | 0.134 |
Moesin | Neg. | 824 (87%) | Â | Â | Â | Â |
 | Pos. | 118 (13%) | 1.31 (0.91 to 1.89) | 0.145 | 1.95 (.63 to 1.44) | 0.815 |
MUC1 | Neg. | 95 (9%) | Â | Â | Â | Â |
 | Pos. | 938 (91%) | 0.59 (0.42 to 0.86) | 0.005 | 0.77 (0.51 to 1.16) | 0.213 |
P21 | Neg. | 378 (41%) | Â | Â | Â | Â |
 | Pos. | 545 (59%) | 0.93 (0.71 to 1.22) | 0.616 | 0.84 (0.62 to 1.13) | 0.241 |
P27 | Neg. | 175 (19%) | Â | Â | Â | Â |
 | Pos. | 768 (81%) | 0.89 (0.65 to 1.24) | 0.509 | 1.06 (0.75 to 1.50) | 0.754 |
P53 | Neg. | 746 (75%) | Â | Â | Â | Â |
 | Pos. | 246 (25%) | 1.59 (1.21 to 2.07) | <.001 | 1.29 (0.95 to 1.75) | 0.107 |
P-Cadherin | Neg. | 570 (61%) | Â | Â | Â | Â |
 | Pos. | 371 (39%) | 1.44 (1.12 to 1.87) | 0.005 | 1.31 (0.96 to 1.78) | 0.089 |
PR | Neg. | 488 (46%) | Â | Â | Â | Â |
 | Pos. | 581 (54%) | 0.54 (0.42 to 0.69) | <0.001 | 0.66 (0.47 to 0.92) | 0.013 |
PTEN | Neg. | 314 (34%) | Â | Â | Â | Â |
 | Pos. | 610 (66%) | 1.00 (0.76 to 1.33) | 0.977 | 1.00 (0.74 to 1.36) | 0.991 |
TACC2 | Neg. | 148 (17%) | Â | Â | Â | Â |
 | Pos. | 723 (83%) | 1.05 (0.73 to 1.52) | 0.777 | 0.95 (0.64 to 1.42) | 0.796 |
TACC3 | Neg. | 35 (6%) | Â | Â | Â | Â |
 | Pos. | 564 (94%) | 1.83 (0.75 to 4.47) | 0.179 | 1.17 (0.47 to 2.88) | 0.738 |
TAU | Neg. | 685 (83%) | Â | Â | Â | Â |
 | Pos. | 141 (17%) | 0.56 (0.36 to 0.88) | 0.011 | 0.75 (0.47 to 1.21) | 0.243 |
TOPO2A | Neg. | 199 (22%) | Â | Â | Â | Â |
 | Pos. | 714 (78%) | 1.41 (0.99 to 2.00) | 0.052 | 1.39 (0.93 to 2.07) | 0.104 |