From: Choosing the right cell line for breast cancer research
Classification | Immunoprofile | Other characteristics | |
---|---|---|---|
Luminal A | ER+, PR+/-, HER2- | Ki67 low, endocrine responsive, often chemotherapy responsive | MCF-7, T47D, SUM185 |
Luminal B | ER+, PR+/-, HER2+ | Ki67 high, usually endocrine responsive, variable to chemotherapy. HER2+ are trastusumab responsive | BT474, ZR-75 |
Basal | ER-, PR-, HER2- | EGFR+ and/or cytokeratin 5/6+, Ki67 high, endocrine nonresponsive, often chemotherapy responsive | MDA-MB-468, SUM190 |
Claudin-low | ER-, PR-, HER2- | Ki67, E-cadherin, claudin-3, claudinin-4 and claudinin-7 low. Intermediate response to chemotherapy | BT549, MDA-MB-231, Hs578T, SUM1315 |
HER2 | ER-, PR-, HER2+ | Ki67 high, trastusumab responsive, chemotherapy responsive | SKBR3, MDA-MB-453 |