|  | RFS | OS | ||||
---|---|---|---|---|---|---|---|
Variable | Number of patients | Events | 5-year RFS | HR (95% CI) | Events | 5-year OS | HR (95% CI) |
T | Â | Â | Â | Â | Â | Â | Â |
   1 | 35 | 8 | 74.2 | 1 | 6 | 84.2 | 1 |
   2 | 46 | 15 | 65.9 | 1.51 (0.64 to 3.58) | 10 | 74.3 | 1.30 (0.47 to 3.60) |
   3 or 4 | 5 | 2 | 53.3 | 2.15 (0.45 to 10.4) | 1 | 80.0 | 1.34 (0.16 to 11.3) |
 |  | P = 0.510* | P = 0.868* | ||||
N | Â | Â | Â | Â | Â | Â | Â |
   N- | 35 | 4 | 88.1 | 1 | 2 | 94.2 | 1 |
   N+ | 51 | 21 | 55.8 | 3.94 (1.35 to 11.5) | 15 | 70.0 | 4.89 (1.12 to 21.4) |
 |  | P = 0.007* | P = 0.020* | ||||
SBR | Â | Â | Â | Â | Â | Â | Â |
   2 | 36 | 5 | 84.9 | 1 | 4 | 89.4 | 1 |
   3 | 49 | 20 | 55.8 | 3.80 (1.42 to 10.2) | 13 | 70.8 | 2.96 (0.96 to 9.15) |
 |  | P = 0.004* | P = 0.048* | ||||
ER | Â | Â | Â | Â | Â | Â | Â |
   ER- | 60 | 19 | 66.9 | 1 | 13 | 76.2 | 1 |
   ER+ | 26 | 6 | 70.1 | 0.64 (0.25 to 1.60) | 4 | 84.9 | 0.68 (0.22 to 2.10) |
 |  | P = 0.333* | P = 0.505* | ||||
PR | Â | Â | Â | Â | Â | Â | Â |
   PR- | 44 | 18 | 57.6 | 1 | 13 | 67.3 | 1 |
   PR+ | 42 | 7 | 80.9 | 0.36 (0.15 to 0.87) | 4 | 92.4 | 0.32 (0.10 to 0.99) |
 |  | P = 0.018* | P = 0.037* | ||||
ER/PR | Â | Â | Â | Â | Â | Â | Â |
   ER-/PR- | 42 | 17 | 58.7 | 1 | 12 | 68.9 | 1 |
   Other | 44 | 8 | 78.2 | 0.39 (0.17 to 0.91) | 5 | 89.2 | 0.40 (0.14 to 1.14) |
 |  | P = 0.024* | P = 0.076* | ||||
MED1 | Â | Â | Â | Â | Â | Â | Â |
   Del/Nm | 30 | 10 | 66.2 | 1 | 7 | 72.9 | 1 |
   Amp | 56 | 15 | 70.0 | 0.76 (0.34 to 1.70) | 10 | 82.5 | 0.63 (0.23 to 1.69) |
 |  | P = 0.507* | P = 0.354* | ||||
STARD3 | Â | Â | Â | Â | Â | Â | Â |
   Del/Nm | 6 | 2 | 55.6 | 1 | 2 | 53.3 | 1 |
   Amp | 80 | 23 | 69.4 | 0.85 (0.20 to 3.62) | 15 | 80.9 | 0.48 (0.11 to 2.14) |
 |  | P = 0.826* | P = 0.327* | ||||
GRB7 | Â | Â | Â | Â | Â | Â | Â |
   Del/Nm | 2 | 1 | 50.0 | 1 | 1 | 0.00 | 1 |
   Amp | 84 | 24 | 69.3 | 0.30 (0.04 to 2.33) | 16 | 80.1 | 0.15 (0.02 to 1.20) |
 |  | P = 0.225* | P = 0.038* | ||||
THRA | Â | Â | Â | Â | Â | Â | Â |
   Del/Nm | 39 | 16 | 59.0 | 1 | 11 | 73.8 | 1 |
   Amp | 47 | 9 | 79.3 | 0.50 (0.22 to 1.13) | 6 | 84.7 | 0.53 (0.19 to 1.43) |
 |  | P = 0.090* | P = 0.199* | ||||
RARA | Â | Â | Â | Â | Â | Â | Â |
   Del/Nm | 63 | 21 | 64.1 | 1 | 15 | 75.2 | 1 |
   Amp | 23 | 4 | 82.4 | 0.50 (0.17 to 1.45) | 2 | 91.3 | 0.36 (0.08 to 1.59) |
 |  | P = 0.190* | P = 0.162* | ||||
TOP2A | Â | Â | Â | Â | Â | Â | Â |
   Del/Nm | 63 | 21 | 63.7 | 1 | 15 | 74.8 | 1 |
   Amp | 23 | 4 | 82.4 | 0.47 (0.16 to 1.38) | 2 | 91.3 | 0.34 (0.08 to 1.48) |
 |  | P = 0.159* | P = 0.132* | ||||
IGFBP4 | Â | Â | Â | Â | Â | Â | Â |
   Del/Nm | 68 | 21 | 66.6 | 1 | 15 | 76.9 | 1 |
   Amp | 18 | 4 | 77.4 | 0.70 (0.24 to 2.06) | 2 | 88.9 | 0.49 (0.11 to 2.16) |
 |  | P = 0.520* | P = 0.335* | ||||
CCR7 | Â | Â | Â | Â | Â | Â | Â |
   Del/Nm | 68 | 21 | 67.0 | 1 | 16 | 75.3 | 1 |
   Amp | 18 | 4 | 75.4 | 0.66 (0.22 to 1.93) | 1 | 94.4 | 0.21 (0.03 to 1.61) |
 |  | P = 0.442* | P = 0.099* | ||||
KRT20 | Â | Â | Â | Â | Â | Â | Â |
   Del/Nm | 74 | 21 | 69.2 | 1 | 15 | 78.8 | 1 |
   Amp | 12 | 4 | 66.7 | 1.31 (0.45 to 3.81) | 2 | 81.5 | 1.02 (0.23 to 4.49) |
 |  | P = 0.622* | P = 0.981* | ||||
KRT19 | Â | Â | Â | Â | Â | Â | Â |
   Del/Nm | 76 | 23 | 67.6 | 1 | 16 | 78.3 | 1 |
   Amp | 10 | 2 | 78.7 | 0.70 (0.16 to 2.96) | 1 | 90.0 | 0.64 (0.08 to 4.82) |
 |  | P = 0.624* | P = 0.658* | ||||
GAS | Â | Â | Â | Â | Â | Â | Â |
   Del/Nm | 80 | 24 | 68.0 | 1 | 16 | 79.1 | 1 |
   Amp | 6 | 1 | 83.3 | 0.64 (0.09 to 4.74) | 1 | 83.3 | 1.21 (0.16 to 9.20) |
 |  | P = 0.660* | P = 0.852* | ||||
ER-/PR- and TOP2A Del/Nm | 30 | 15 | 49.2 | 1 | 11 | 61.0 | 1 |
Others | 56 | 10 | 79.2 | 0.29 (0.13 to 0.65) | 6 | 89.7 | 0.28 (0.10 to 0.76) |
 |  | P = 0.001* | P = 0.008* |