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Table 1 Mechanisms whereby estrogen may enhance cognitive function

From: Do aromatase inhibitors have adverse effects on cognitive function?

• Enhancement of cholinergic and glutamate neurotransmitter systems [13–15]

• Enhancement of neuronal survival, differentiation, regeneration, and plasticity [16, 17]

• Favorable effect on serum lipid profiles [18]

• Modulation of expression of apolipoprotein E [19]

  1. Note: the relationship between estrogen and cognitive function is complex and likely non-linear.
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Breast Cancer Research

ISSN: 1465-542X

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