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Table 2 Estimated per-allele odds ratios and 95% confidence intervals for 12 SNPs, by availability of non-genetic risk factor information*

From: Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study

SNP

Genes at locus

Alleles†

MAF††

OR (95%CI)‡

OR (95%CI)‡‡based on subjects with data available on:

    

All subjects

Age menarche

Parity

Age at first birth

Body mass index#

10q26-rs2981582

FGFR2

CT

0.38

1.22 (1.19 to 1.26)

1.22 (1.19 to 1.26)

1.22 (1.19 to 1.26)

1.22 (1.18 to 1.26)

1.21 (1.17 to 1.25)

    

(25,821/22,551)

(20,134/18,697)

(21,985/20,111)

(15,204/15,359)

(16,883/18,660)

8q24-rs13281615

intergenic

AG

0.41

1.12 (1.09 to 1.15)

1.12 (1.09 to 1.16)

1.12 (1.09 to 1.16)

1.13 (1.09 to 1.17)

1.13 (1.10 to 1.17)

    

(21,823/20,609)

(16,779/16,698)

(18,060/18,081)

(11,808/13,610)

(12,969/16,531)

11p15-rs3817198

LSP1

TC

0.31

1.08 (1.05 to 1.11)

1.08 (1.05 to 1.12)

1.08 (1.05 to 1.11)

1.09 (1.05 to 1.13)

1.08 (1.05 to 1.12)

    

(25,004/21,596)

(19,439/17,896)

(21,268/19,249)

(14,655/14,661)

(16,191/17,810)

5q11-rs889312

MAP3K1

AC

0.28

1.11 (1.08 to 1.15)

1.10 (1.06 to 1.13)

1.11 (1.07 to 1.14)

1.09 (1.05 to 1.13)

1.09 (1.06 to 1.13)

    

(26,227/23,307)

(20,557/19,306)

(22,407/20,855)

(15,573/15,943)

(17,304/19,335)

16q12-rs3803662

TOX3/TNRC9

CT

0.26

1.23 (1.19 to 1.26)

1.22 (1.18 to 1.26)

1.24 (1.20 to 1.27)

1.21 (1.17 to 1.26)

1.23 (1.19 to 1.27)

    

(26,132/23,459)

(20,628/19,334)

(22,478/20,874)

(15,613/15,966)

(17,356/19,351)

2q35-rs13387042

intergenic

GA

0.52

1.14 (1.11 to 1.17)

1.13 (1.10 to 1.16)

1.13 (1.11 to 1.16)

1.13 (1.10 to 1.17)

1.14 (1.11 to 1.18)

    

(32,917/25,996)

(26,581/21,507)

(29,037/23,157)

(23,757/17,897)

(20,286/21,609)

5p12-rs10941679

MRPS30

AG

0.26

1.12 (1.09 to 1.15)

1.13 (1.09 to 1.16)

1.12 (1.08 to 1.15)

1.13 (1.09 to 1.17)

1.12 (1.08 to 1.16)

    

(31,513/25,008)

(25,399/20,992)

(27,436/22,456)

(22,334/17,356)

(18,568/20,370)

17q23-rs6504950

COX11, STXBP4

GA

0.28

0.95 (0.92 to 0.97)

0.95 (0.92 to 0.98)

0.95 (0.92 to 0.97)

0.94 (0.91 to 0.98)

0.94 (0.91 to 0.97)

    

(30,045/23,943)

(24,114/19,454)

(26,246/21,094)

(21,294/16,138)

(17,497/19,500)

3p24-rs4973768

SLC4A7, NEK10

CT

0.46

1.11 (1.09 to 1.14)

1.10 (1.07 to 1.13)

1.11 (1.08 to 1.14)

1.10 (1.07 to 1.14)

1.11 (1.08 to 1.14)

    

(30,366/22,929)

(24,483/18,624)

(26,707/20,292)

(21,733/15,454)

(17,892/18,618)

2q33-rs17468277

CASP8

CT

0.13

0.94 (0.91 to 0.98)

0.95 (0.91 to 0.99)

0.96 (0.92 to 0.99)

0.94 (0.90 to 0.99)

0.96 (0.92 to 0.99)

    

(32,784/25,700)

(26,702/21,218)

(29,020/22,864)

(23,718/17,637)

(20,228/21,267)

19q13-rs1982073

TGFB1

TC

0.38

1.04 (1.01 to 1.07)

1.04 (1.01 to 1.08)

1.04 (1.01 to 1.08)

1.05 (1.01 to 1.09)

1.04 (1.00 to 1.08)

    

(24,498/17,003)

(19,838/14,279)

(20,424/14,950)

(17,050/11,460)

(11,849/13,586)

6q25-rs3020314

ESR1

TC

0.32

1.03 (1.00 to 1.06)

1.02 (0.99 to 1.06)

1.02 (0.99 to 1.05)

1.02 (0.99 to 1.06)

1.01 (0.98 to 1.05)

    

(24,009/20,496)

(19,378/17,622)

(20,623/18,515)

(17,370/14,538)

(15,505/17,167)

  1. *The number of controls/cases (respectively) included in each analysis is given in square parenthesis.
  2. †Minor allele according to first publication in bold type.
  3. ††Minor allele frequency, assessed in controls with available genotype data.
  4. ‡Odds ratio per copy of the minor allele, adjusted for study (categorical), based on all genotype data, regardless of availability of non-genetic risk factor data.
  5. ‡‡Odds ratio per copy of the minor allele, adjusted for age (categorical: ≤34, 35 to 39, 40 to 44, 45 to 49, 50 to 54, 55 to 59, 60 to 64, 65 to 69, 70 to 74, ≥75; and continuous), study and the corresponding non-genetic risk factor (continuous), based on data for subjects with genotype data and information on the non-genetic risk factor.
  6. #Model also included an interaction term for body mass index and age (<55, ≥55).
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Breast Cancer Research

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