| DCIS | IBC | ||||
---|---|---|---|---|---|---|
 | Cystatin M loss |  | Cystatin M loss |  | ||
 | Yes ( n = 9) | No ( n = 108) | P -value | Yes ( n = 99) | No ( n = 76) | P -value |
Age1 | 50 ± 9 | 46 ± 9 | 0.13 | 49 ± 11 | 49 ± 10 | 0.89 |
Tumor size (cm)1 | 2.7 ± 1.8 | 3.0 ± 2.1 | 0.87 | 2.9 ± 1.3 | 2.6 ± 1.1 | 0.27 |
Number of LN1 | 0 | 0.4 ± 1.1 | 0.69 | 2.6 ± 5.0 | 3.1 ± 5.9 | 0.83 |
Family history | Â | Â | Â | Â | Â | Â |
   No | 9 | 104 |  | 92 | 72 |  |
   Yes | 0 | 4 | 1.00 | 7 | 4 | 0.76 |
Histologic grade | Â | Â | Â | Â | Â | Â |
   I | 1 | 24 |  | 8 | 8 |  |
   II | 5 | 48 |  | 42 | 39 |  |
   III | 3 | 36 | 0.90 | 49 | 29 | 0.32 |
ER | Â | Â | Â | Â | Â | Â |
   Negative | 1 | 32 |  | 50 | 24 |  |
   Positive | 8 | 76 | 0.44 | 49 | 52 | 0.01 |
PR | Â | Â | Â | Â | Â | Â |
   Negative | 3 | 42 |  | 62 | 30 |  |
   Positive | 6 | 66 | 1.00 | 37 | 46 | 0.002 |
HER2 | Â | Â | Â | Â | Â | Â |
   Negative | 3 | 46 |  | 58 | 43 |  |
   Positive | 6 | 62 | 0.73 | 41 | 33 | 0.79 |
HER4 | Â | Â | Â | Â | Â | Â |
   Negative | 7 | 37 |  | 34 | 11 |  |
   Positive | 2 | 71 | 0.03 | 65 | 65 | 0.003 |
Stage | Â | Â | Â | Â | Â | Â |
   I |  |  |  | 21 | 14 |  |
   II |  |  |  | 55 | 43 |  |
   III |  |  |  | 22 | 18 |  |
   IV |  |  |  | 1 | 2 | 0.86 |