Figure 1From: 17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2Schematic of choline phospholipid metabolism. Schematic drawing of choline phospholipid metabolism and its regulatory enzymes illustrates the metabolic reactions associated with modulation of choline-containing metabolites. CCT, CTP:phosphocholine cytidylyltransferase; CDP-choline, cytidine diphosphate-choline; ChoK, choline kinase; CPT, diacylglycerol cholinephosphotransferase; GDPD, glycerophosphocholine phosphodiesterase; GPC, glycerophosphocholine; LPL, lysophospholipase; PC, phosphocholine; PLA, phospholipase A; PLC, phospholipase C; PLD, phospholipase D; PtdCho, phosphatidylcholine.Back to article page