Figure 4From: Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancerEpithelial differentiation score analysis of normal mammary tissue, human breast tumors, human cell lines and mouse mammary tumors. (a) Differentiation axis based on Lim et al. [24] data. (b) Mammospheres (MMS; n = 14) derived from normal breast tissue. Yellow crosses identify claudin-low MMS (n = 6, 43%) as defined by the nine-cell line claudin-low predictor. (c) Tumors and the normal breast-like group from the UNC337 database. (d) Breast cancer cell lines. Except for the nine claudin-low cell lines, we used the subtype calls (luminal [L] and basal [B]) as reported in Neve et al. [21]. (e) Mouse tumors from Herschkowitz et al. [5]. (f) Histological special types of breast cancer obtained from the NKI113 database [14]. Colored dots or boxes denote the subtype cells. IDC with OGC, invasive ductal carcinoma with osteoclastic giant cells; ILC, invasive lobular carcinoma; BL (red), basal-like; CL (yellow), claudin-low defined by the nine-cell line claudin-low predictor; H2 (pink), HER2-enriched; LA (dark blue), luminal A; LB (light blue), luminal B; NBL (green), normal breast-like. *P < 0.0001.Back to article page