From: The contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis
Stage | Stromal changes | Growth factors/matrix |
---|---|---|
PABC | Macrophage recruitment, inflammation, angiogenesis, adipocyte remodeling | ECM degradation, MCP-1, CSF-1, IGF, HGF, TGF beta, systemic estrogen |
Postmenopause | Aromatase, epithelial atrophy, stromal replacement, adipocyte remodeling | Local estrogen, lumican, decorin, collagen |
Postmenopause with obesity | Macrophages, inflammation, angiogenesis, aromatase, reactive adipose | IGF, HGF, MCP-1, TGF beta, local and systemic estrogen |